We present the case of an adolescent with nocturnal enuresis since childhood, and anxiety symptoms during adolescence associated with psychosocial factors and family dynamics. During the COVID-19 pandemic, he presented intense symptoms of anxiety in relation to the fear of having a serious illness and the fear of dying, which is why he was taken to the emergency room on several occasions. Exacerbating the symptoms of enuresis and presenting the anxiety disorder due to illness. Responding favorably to antidepressant drugs, individual and family psychotherapy. Being nocturnal enuresis a rare elimination disorder in adolescence, whose diagnosis and treatment are important due to the risk of affecting psychosocial functioning and greater probability of presenting comorbidity. Likewise, we mention the impact of the COVID-19 pandemic on adolescents, due to a higher risk of presenting anxiety, depression and stress associated with enuresis.