Psychiatric comorbidity in women with polycystic ovary syndrome

Annagür, Bılge Burçak; Kerimoğlu, Özlem Seçilmiş; Tazegül, Aybike; Gündüz, Şule; Gençoğlu, Berat Berrin

doi:10.1111/jog.12696

Cited by 40 publications

(47 citation statements)

References 33 publications

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“…Many studies demonstrated high rates of depression, between 40% and 60%, in women with PCOS (Kerchner et al, 2009). Depression and anxiety disorders were also found to be the most common comorbid psychiatric conditions in patients with PCOS in Turkey (Annagür et al, 2015). Both depressive and anxiety disorders were increased in the first year after a diagnosis of PCOS (Okamura et al, 2000).…”

Section: Discussionmentioning

confidence: 96%

Evaluation of affective temperament and anxiety–depression levels of patients with polycystic ovary syndrome

Aşık

Altınbaş

Eroğlu

et al. 2015

Journal of Affective Disorders

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Section: Discussionmentioning

confidence: 96%

Evaluation of affective temperament and anxiety–depression levels of patients with polycystic ovary syndrome

Aşık

Altınbaş

Eroğlu

et al. 2015

Journal of Affective Disorders

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“…Anecdotally, women with PCOS appear to have difficulty with diet and weight management. Lifestyle modifications are first‐line management for treatment of PCOS in overweight or obese women, and weight loss has been shown to improve menstrual regularity, cardio‐metabolic risk factors and androgen excess . Despite the association between PCOS and obesity, along with the role of diet and weight loss in treatment, limited data exist on the best intervention to achieve sustainable lifestyle modifications.…”

Section: Introductionmentioning

confidence: 99%

Eating, sleeping and sexual function disorders in women with polycystic ovary syndrome (PCOS): A systematic review and meta‐analysis

Thannickal

Brutocao

Alsawas

et al. 2020

Clinical Endocrinology

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Purpose We aim to evaluate the association of PCOS with eating, sleeping and sexual function disorders. Methods A comprehensive search including MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus through 01 August 2018 was conducted for studies reporting the prevalence of any eating, sleep or sexual function disorders in patients with PCOS. Independent reviewers selected studies and extracted data. A random‐effects model was utilized to generate pooled odds ratio (OR) and 95% confidence intervals (CI) for binary outcomes, and mean difference (MD) and 95% CI for continuous outcomes. Results We included 36 studies reporting on 349,529 patients. Compared to women without PCOS, women with PCOS were more likely to have bulimia nervosa (OR 1.37; %CI, 1.17 to 1.60), binge eating (OR 2.95; 95%CI, 1.61 to 5.42), or any eating disorder (OR 1.96; 95% CI 1.18 to 3.24); but not anorexia nervosa (OR 0.92; 95%CI, 0.78 to 1.10). Women with PCOS were more likely to have sleep disorders like hypersomnia (OR 4.39; %CI, 1.07 to 18.07) and obstructive sleep apnoea (OR 10.81; %CI, 2.39 to 48.83). Women with PCOS had lower sexual satisfaction as measured on a visual analogue scale (MD −29.67; 95% CI, −36.97 to −22.37), but no difference in Total Female Sexual Function Index (MD −0.06; 95% CI, −0.51 to 0.38). Conclusion PCOS can be associated with an increased risk of eating and sleeping disorders as well as decreased sexual satisfaction. Screening for these disorders in women with PCOS may allow early intervention and improve quality of life.

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“…Numerous studies have evaluated the relation between PCOS and psychiatric disorders; however, most have evaluated psychiatric symptoms based on self-report measures 1,3. There remains, therefore, an unclear relationship between PCOS and psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis

Blay¹,

Aguiar²,

Passos³

2016

NDT

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BackgroundThe association between depression, anxiety, and polycystic ovary syndrome (PCOS) is still unclear. Therefore, a systematic review and meta-analysis was conducted to assess the rates of comorbid psychiatric disorders among women with PCOS compared to women without it.MethodsPubMed/MEDLINE, Embase, PsycINFO, and Web of Science databases were searched from inception to November 27, 2015. Studies were eligible for inclusion if they were original reports in which the rates of mood (bipolar disorder, dysthymia, or major depressive disorder), obsessive–compulsive spectrum disorders, trauma- and stressor-related disorders, anxiety disorders or psychotic disorders, somatic symptom and related disorders, or eating disorders had been investigated among women with an established diagnosis of PCOS and compared with women without PCOS. Psychiatric diagnosis should have been established by means of a structured diagnostic interview or through a validated screening tool. Data were extracted and pooled using random effects models.ResultsSix studies were included in the meta-analysis; of these, five reported the rates of anxiety and six provided data on the rates of depression. The rate of subjects with anxiety symptoms was higher in patients with PCOS compared to women without PCOS (odds ratio (OR) =2.76; 95% confidence interval (CI) 1.26 to 6.02; Log OR =1.013; P=0.011). The rate of subjects with depressive symptoms was higher in patients with PCOS compared to women without PCOS (OR =3.51; 95% CI 1.97 to 6.24; Log OR =1.255; P<0.001).ConclusionAnxiety and depression symptoms are more prevalent in patients with PCOS.

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Psychiatric comorbidity in women with polycystic ovary syndrome

Abstract: A considerable number of women with PCOS experience a psychiatric disorder during their lifetime. Clinicians should be aware that women with PCOS are at a high risk for major depression, generalized anxiety disorder, and binge-eating disorder.

Cited by 40 publications

References 33 publications

Evaluation of affective temperament and anxiety–depression levels of patients with polycystic ovary syndrome

Evaluation of affective temperament and anxiety–depression levels of patients with polycystic ovary syndrome

Eating, sleeping and sexual function disorders in women with polycystic ovary syndrome (PCOS): A systematic review and meta‐analysis

Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis

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