Psoriatic onycho-pachydermo-periostitis. A variant of psoriatic distal interphalangeal arthritis?

Boisseau‐Garsaud, Anne‐Marie

doi:10.1001/archderm.132.2.176

Cited by 24 publications

(51 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,2). Die Nagelplatten weisen ein gelbliches Kolorit auf, sind verdickt und stellenweise vom Nagelbett abgelöst.…”

Section: Dermatologischer Befundunclassified

“…POPP, so erklärt sich die Erkrankung aus dem unterschiedlichen Ausmaß eicharakteristisch dagegen werden die röntgenologischen Veränderungen an den Endphalangen von Fingern und Zehen gewertet [7,15]. Hier finden sich regelmäßig eine Osteoperiostitis mit zahlreichen irregulären lateralen Periostappositionen, deren Formen an Stacheln oder Dornen erinnern können, blumenkohlartig veränderte distale Knochenkonturen ("en chou fleur"), inhomogene Knochenverdichtungen, Erosionen und Mikrolakunen [1,7] [13]. Insofern erscheint die Berücksichtigung auch anderer pathogenetischer Möglichkeiten gerechtfertigt [8,17].…”

Section: Röntgenologische Befundeunclassified

“…Die Autoren nannten das von ihnen beschriebene klinisch-radiologische Syndrom OP3GO. In der Folge kam es zur Beschreibung sehr ähnli-cher Symptomenkomplexe, die ebenfalls meistens im Zehenbereich, gelegentlich in Abweichung von der Originalarbeit auch einseitig [9], an anderen als den Großzehen oder sogar im Bereich aller Endphalangen von Füßen und Händen ausgeprägt waren und gelegentlich eine Arthritis der DIP einschlossen [1,4,14]. Da hinsichtlich der prinzipiellen Identität dieser klinischen Bilder mit der Erstbeschreibung keine Zweifel bestanden, trat die Bezeichnung psoriatische Onychopachydermoperiostitis (POPP) neben den ausschließ-lich auf einen Großzehenbefall orien-…”

Section: Introductionunclassified

See 2 more Smart Citations

Psoriasiforme Onychopachydermoperiostitis der Großzehen: Das OP3GO-Syndrom

Ziemer

Heider²,

Göring

1998

Der Hautarzt

View full text Add to dashboard Cite

A 46-years old male patient suffered for several years from painful swelling of the distal soft tissues of the great toes associated with onychodystrophy. Mycological studies were negative. By means of radiological and scintigrafic examination and because of the typical clinical signs, the diagnosis of psoriatic onycho-pachydermo-periostitis of the great toes was established. The syndrome which is highly evocative of rheumatoid psoriasis was first described by Fournié and co-workers in 1989. Oral retinoids were helpful in diminishing both pain and soft tissue swelling of the great toes.

show abstract

“…1,2). Die Nagelplatten weisen ein gelbliches Kolorit auf, sind verdickt und stellenweise vom Nagelbett abgelöst.…”

Section: Dermatologischer Befundunclassified

Section: Röntgenologische Befundeunclassified

Section: Introductionunclassified

See 1 more Smart Citation

Psoriasiforme Onychopachydermoperiostitis der Großzehen: Das OP3GO-Syndrom

Ziemer

Heider²,

Göring

1998

Der Hautarzt

View full text Add to dashboard Cite

show abstract

“…POPP can be extremely painful and frequently causes significant fuctional impairment. It has been recognized as an uncommon subset of psoriatic arthritis and, to date, only a few cases have been described (1)(2)(3)(4). In general, POPP is regarded as a unique variant of psoriatic arthritis, but its pathology and pathophysiology are not well understood.…”

mentioning

confidence: 99%

Clinical images: Drumstick‐like fingers indicating psoriatic onycho‐pachydermo periostitis

Tsubota

Abe

Shibaki

2005

Arthritis & Rheumatism

View full text Add to dashboard Cite

The patient, a 38-year-old man with a 10-year history of deformation and pustules in his fingers and toes, presented in December 2002. Physical examination revealed tender, drumstick-like swelling in all of his fingers and toes. Erythematous, scaling, and pustular eruptions were observed on the distal area of the digits (A). The nail plates were completely destroyed. He reported having arthralgia in the distal area of the digits. Scaly erythematous and pustular eruptions were present on the forehead and right knee. Radiographs of the fingers and toes revealed remarkable bone resorption and destruction, especially in the distal phalanges (B). Histologic examination of sections of a skin lesion showed parakeratosis and neutrophils forming Munro's abscesses in the stratum corneum. Rheumatoid factor was negative. Based on the above-mentioned findings, the patient was diagnosed as having psoriatic onycho-pachydermo periostitis (POPP) combined with an axial manifestation of psoriatic arthritis. POPP was described by Fournie et al in 1989 (1). It consists of psoriatic onychodystrophy and connective tissue thickening above the distal phalanx, including a periosteal reaction. POPP can be extremely painful and frequently causes significant fuctional impairment. It has been recognized as an uncommon subset of psoriatic arthritis and, to date, only a few cases have been described (1-4). In general, POPP is regarded as a unique variant of psoriatic arthritis, but its pathology and pathophysiology are not well understood. Therapy for this rare disease is based on treatments used for psoriatic arthritis, such as sulfasalazine, methotrexate, and the anti-tumor necrosis factor antibody adalimumab (4).

show abstract

“…5 In contrast, bony involvement of the terminal phalanx under a psoriatic nail is rare. 6 The approximate time of progress from the initiation of nail changes to the beginning of erosion or deformity in digits has not been reported in the literature except in one case where it was observed that psoriatic onychodystrophy and painful swellings of the toes and fingers developed within six months. 7 In our case, painful swelling and tenderness of the fingers started three to four weeks after nail changes were observed and within three months as of the development of the flexion deformities of the DIP joints.…”

Section: Discussionmentioning

confidence: 98%

A Rapidly Progressive Variant of Psoriatic Arthritis: Psoriatic Onycho-Pachydermo-Periostitis

2016

View full text Add to dashboard Cite

It is an uncommon subset of psoriatic arthritis that is characterized by psoriatic onychodystrophy, onycholysis, connective tissue thickening above the distal phalanx as well as specific radiologic changes such as periosteal reaction and bone erosions of the distal phalanges.1 In this article, the case of a 53-year-old male patient with POPP who responded dramatically to methotrexate has been discussed. CASE REPORTA 53-year-old male patient was admitted to the dermatology clinic with nail changes and pain in all the fingers, which started approximately one year prior to admission. His nail biopsies were unremarkable and his condition was unresponsive to anti-fungal medications ordered by several dermatology clinics over the past one year. Thereafter, the patient was referred to our clinic for flexion deformity of the distal interphalangeal (DIP) joints. He had painful swellings with functional impairment in the DIP joints for seven to eight months after which the deformities started to develop. A written informed consent was obtained from the patient.Our patient was working as a documentalist with no history of trauma or repetitive injury. On rheumatologic evaluation, there were no remarkable findings such as recurrent genital aphthous ulcers, oral aphthous ulcers, dry eyes and mouth, back pain, morning stiffness, bowel related symptoms, repeated fever or abdominal pain, and any other dermatologic rash. He had no systemic diseases, history of infection, recent vaccinations, or regular drug use. Family history was negative for psoriasis or other skin diseases. A physical examination revealed erythematous swellings and flexion deformities in all the DIP joints. All the fingernails had severe dystrophic changes. A psoriatic plaque was present on the extensor surface of the right elbow. ABSTRACTWe present a case with psoriatic onychodystrophy, onycholysis, connective tissue thickening above the distal phalanx as well as specific radiologic changes diagnosed as psoriatic onycho-pachydermo-periostitis who responded dramatically to methotrexate with current literature review. In this article, we report a 53-year-old male patient with psoriatic onycho-pachydermo-periostitis who responded dramatically to methotrexate.

show abstract

Psoriatic onycho-pachydermo-periostitis. A variant of psoriatic distal interphalangeal arthritis?

Cited by 24 publications

References 0 publications

Psoriasiforme Onychopachydermoperiostitis der Großzehen: Das OP3GO-Syndrom

Psoriasiforme Onychopachydermoperiostitis der Großzehen: Das OP3GO-Syndrom

Clinical images: Drumstick‐like fingers indicating psoriatic onycho‐pachydermo periostitis

A Rapidly Progressive Variant of Psoriatic Arthritis: Psoriatic Onycho-Pachydermo-Periostitis

Contact Info

Product

Resources

About