Psoriasis Patients Have Abnormal Ceramide Profile in Stratum Corneum

Koyano, Satomi; Hatamochi, Atsushi; Yamazaki, Soji; Ishikawa, Junko; Kitahara, Takashi; Narita, Hirofumi; Kondo, Naohide; Masukawa, Yoshinori

doi:10.2336/nishinihonhifu.72.494

Cited by 15 publications

(18 citation statements)

References 10 publications

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“…Thus, the ameliorating effect of pCer on the water-holding function (conductance) is much greater than on the barrier function (TEWL), which seems to reflect the increased levels of the Cer [NH] and Cer [NP] classes, which play a role in the waterholding function in the pCer lotionetreated skin of patients with AD (Matsuki et al, 2004b). In contrast, it should be noted that because similar patterns of ceramide profiles including carbon chain lengths were observed in both the lesional skin of patients with AD and of patients with psoriasis (Koyano et al, 2010), these alterations in ceramide profiles seem to be not AD-specific or psoriasisspecific but are inflammation-specific. Similar inflammationassociated alterations in ceramide profiles were reported by Kim et al (2017), who demonstrated that the SC of nonlesional skin in allergic contact dermatitis exhibits abnormalities in barrier function and ceramide profiles similar to those in AD skin.…”

Section: Discussionmentioning

confidence: 94%

Treatment with Synthetic Pseudoceramide Improves Atopic Skin, Switching the Ceramide Profile to a Healthy Skin Phenotype

Ishida

Takahashi

Bito

et al. 2020

Journal of Investigative Dermatology

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Little is known about the pathophysiological linkages between altered ceramide profiles in the stratum corneum (SC) of patients with atopic dermatitis and their impaired skin barrier and water-holding functions. We studied those characteristics following topical treatment with a designed synthetic pseudoceramide (pCer) and analyzed that pathophysiological linkage by microanalyzing ceramides using normal phase liquid chromatographyeelectrospray ionization mass spectrometry. Four weeks of treatment with pCer significantly reduced skin symptoms, accompanied by significant decreases in transepidermal water loss and increases in water content. In the SC ceramide profiles, ceramides containing nonhydroxy fatty acids and 6hydroxysphingosines (Cer[NH]) and ceramides containing nonhydroxy fatty acids and phytosphingosines (Cer[NP]) increased, whereas ceramides containing nonhydroxy fatty acids and sphingosines (Cer[NS]) and ceramides containing a-hydroxy fatty acids and sphingosines (Cer[AS]) decreased, with larger alkyl chain lengths in Cer[NS], distinctly representing a switch from an atopic dermatitis to a healthy skin phenotype. The level of pCer that penetrated into the SC was significantly correlated with the SC water content but not with transepidermal water loss. The level and the average carbon chain length of Cer[NS] were closely correlated with the pCer level in the SC. These findings indicate that the penetrated pCer contributes to shift the ceramide profile from an atopic dermatitis to a healthy skin phenotype. Taken together, the observed clinical efficacy of treatment with pCer provides a deep insight into the pathogenesis of atopic dermatitis as a ceramide-deficient disease.

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Section: Discussionmentioning

confidence: 94%

Treatment with Synthetic Pseudoceramide Improves Atopic Skin, Switching the Ceramide Profile to a Healthy Skin Phenotype

Ishida

Takahashi

Bito

et al. 2020

Journal of Investigative Dermatology

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“…Neither the level of C34‐CER[NS] nor the average carbon numbers of each CER class, which have been reported to change significantly in the skin of patients with atopic dermatitis and psoriasis, showed a significant correlation with any of the values (TEWL, conductance, dryness, roughness, and scaliness) (data not shown).…”

Section: Resultsmentioning

confidence: 99%

“…In our previous studies, we developed a method to quantify overall CER species using normal‐phase liquid chromatography‐electrospray ionization‐mass spectrometry (NPLC‐ESI‐MS) to clarify the importance of the CER profile in the SC . In addition, we had reported that the CER profile is abnormal in patients with atopic dermatitis or psoriasis, and that abnormalities of the CER profile correlate with defects of barrier and water holding functions . Recent studies by other groups have also focused on the CER profiles in the SC …”

Section: Introductionmentioning

confidence: 99%

Dry skin in the winter is related to the ceramide profile in the stratum corneum and can be improved by treatment with a Eucalyptus extract

Ishikawa

Yoshida

Ito

et al. 2013

J of Cosmetic Dermatology

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“…The protocol for patients with AD or Pso was approved by the Ethical Committees of the Kao Corporation and the Dokkyo Medical University as described in our previous report [8,9]. Informed consent to participate in the study was obtained from each patient.…”

Section: Ethicsmentioning

confidence: 99%

The ceramide [NP]/[NS] ratio in the stratum corneum is a potential marker for skin properties and epidermal differentiation

et al. 2020

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Background: Specific species of ceramides (Cer), major constituents of lipids in the stratum corneum (SC), are decreased and are correlated with SC barrier and water-holding functions in the skin of patients with atopic dermatitis (AD) or psoriasis (Pso). However, possible correlations between Cer subclass ratios and skin properties in barrier-disrupted skin and in healthy skin remain unclear. The objective of this study was to identify a new marker to evaluate skin properties and epidermal differentiation in SC not only in barrier-disrupted skin but also in healthy skin. Methods: The Cer subclass ratios in the SC of healthy control subjects and in patients with AD or Pso were evaluated. Correlations with candidate markers and facial skin features of healthy Japanese females (20-74 years old, n = 210) were investigated. Variations of markers during epidermal differentiation were studied in human epidermis and in cultured keratinocytes.

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Psoriasis Patients Have Abnormal Ceramide Profile in Stratum Corneum

Cited by 15 publications

References 10 publications

Treatment with Synthetic Pseudoceramide Improves Atopic Skin, Switching the Ceramide Profile to a Healthy Skin Phenotype

Treatment with Synthetic Pseudoceramide Improves Atopic Skin, Switching the Ceramide Profile to a Healthy Skin Phenotype

Dry skin in the winter is related to the ceramide profile in the stratum corneum and can be improved by treatment with a Eucalyptus extract

The ceramide [NP]/[NS] ratio in the stratum corneum is a potential marker for skin properties and epidermal differentiation

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