Psoriasis and risk of celiac disease: A systematic review and meta-analysis

Ungprasert, Patompong; Wijarnpreecha, Karn; Kittanamongkolchai, Wonngarm

doi:10.4103/0019-5154.198031

Cited by 47 publications

(38 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are some evidences to suggest that B and T cells that recognize epitopes presented on gluten proteins can sometimes have cross‐reactivity to self‐antigens . This explanation may also explain why patients with celiac diseases have a higher risk of developing several autoimmune diseases, not only sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 In addition, studies have demonstrated that these patients are at an increased risk of developing several comorbidities including such as psoriasis, chronic kidney disease and venous thromboembolism. [8][9][10][11][12] Sarcoidosis is a multisystemic granulomatous disease of unknown etiology characterized by the formation of noncaseating granuloma c 2019 Chinese Cochrane Center, West China Hospital of Sichuan University and John Wiley & Sons Australia, Ltd in the involved organs. 13 It commonly affects the lungs and intrathoracic lymph node but can virtually affect any organs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Celiac disease and risk of sarcoidosis: A systematic review and meta‐analysis

Wijarnpreecha

Panjawatanan

Corral

et al. 2019

J Evidence Based Medicine

Self Cite

View full text Add to dashboard Cite

Background/objectives Several epidemiologic studies have suggested that patients with celiac disease may be at an increased risk of sarcoidosis but the results were inconsistent. This systematic review and meta‐analysis was conducted with the aim to better characterize this risk by summarizing all available data. Methods A literature review was performed using MEDLINE and EMBASE database from inception to February 2019. Studies that compared the risk of sarcoidosis among patients with celiac disease versus individuals without celiac disease were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random‐effect, generic inverse variance method. Results Of 426 retrieved studies, four studies with 693 639 participants met the eligibility criteria and were included in meta‐analysis. The risk of sarcoidosis among patients with celiac disease was higher than individuals without celiac disease with the pooled OR of 7.16 (95% CI, 1.48‐34.56). The statistical heterogeneity of this study was high (I2 = 95%). Conclusions This systematic review and meta‐analysis found a significantly higher risk of sarcoidosis among patients with celiac disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Celiac disease and risk of sarcoidosis: A systematic review and meta‐analysis

Wijarnpreecha

Panjawatanan

Corral

et al. 2019

J Evidence Based Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Coeliac disease is an immune‐mediated enteropathy characterized clinically by malabsorption and histologically by villous atrophy and crypt hyperplasia. In a meta‐analysis, the risk of coeliac disease has been shown to be increased in patients with psoriasis . However, HLA‐Cw6 was not associated with coeliac disease‐associated antibodies in patients with psoriasis …”

Section: Association With Other Comorbiditiesmentioning

confidence: 99%

HLA-Cw6 and psoriasis

Chen

Tsai

2018

British Journal of Dermatology

129

View full text Add to dashboard Cite

Psoriasis is a multifactorial disease with a strong genetic background. HLA-Cw6 is one of the most strongly associated psoriasis susceptibility alleles. It is repeatedly observed to affect disease course, phenotypic features, severity, comorbidities and treatment outcomes. To the best of our knowledge, the roles of HLA-Cw6 in psoriasis have not yet been thoroughly reviewed. The worldwide frequency of the HLA-Cw6 allele varies greatly, with it being generally higher in white people than in Asians. The allele is associated with type I early-onset psoriasis. Stress, obesity and streptococcal pharyngitis are commonly observed in HLA-Cw6-positive patients. Phenotypically, HLA-Cw6 has been found to be associated with guttate psoriasis. In addition, patients carrying the allele are more likely to have arm, leg and trunk involvement, and the Koebner phenomenon. Patients with psoriatic arthritis with HLA-Cw6 more often have early onset and tend to show cutaneous symptoms before musculoskeletal symptoms. HLA-Cw6-positive patients have been shown in several studies to be more responsive to methotrexate and ustekinumab. However, this difference in ustekinumab efficacy was only moderate in a post-hoc analysis of a pivotal phase III study. HLA-Cw6 positivity also tends to be less frequent in high-need patients who fail conventional therapy. Small studies have also investigated the role of HLA-Cw6 in remission of psoriasis during pregnancy, and with the comorbidities of photosensitivity and atherosclerosis. Given the diverse nature of psoriasis pathogenesis, as well as the difference of HLA-Cw6 positivity in different ethnic groups, more studies are needed to confirm the role of HLA-Cw6 in psoriasis.

show abstract

“…States and approximately 125 million people worldwide [81]. Ps is considered to be a multifactorial disease, in which the genetic background interacts with environmental factors to define the individual's risk [82]. The classical clinical manifestations of Ps consist in the presence of red, infiltrated plaques, covered with a coarse silvery scaling (Figures 14,15).…”

Section: Psoriasismentioning

confidence: 99%

“…For many years, the relationship between Ps and CD remained controversial since the few available data were inconclusive. A recent meta-analysis has demonstrated a significantly higher risk of CD among patients with psoriasis compared with participants without psoriasis with the OR of 3.09 (95%CI= 1.92-4.97) [82]. Furthermore, there are seven studies that have reported a positive association between psoriasis and CD markers [85][86][87][88][89][90][91][92].…”

Section: Psoriasismentioning

confidence: 99%

Cutaneous and Mucosal Manifestations Associated to Celiac Disease

Rodrigo¹,

Beteta²,

Álvarez³

et al. 2018

Preprint

View full text Add to dashboard Cite

Celiac disease (CD) is an immune-mediated gluten-induced enteropathy that affects predisposed individuals of all ages. Many patients with CD do not report gastrointestinal symptoms making it difficult to reach an early diagnosis. On the other hand, CD is related to a wide spectrum of extra-intestinal manifestations, being dermatitis herpetiformis (DH) the best characterized. These associated conditions may be the clue for reaching the diagnosis of CD. Over the last years, there have been multiple reports of the association between CD and several cutaneous manifestations that may improve with a gluten-free diet (GFD). The presence of some of these skin diseases, even in absence of gastrointestinal symptoms, should give rise to an appropriate screening for CD. The aim of this paper is to describe the different cutaneous manifestations that have been associated to CD and the possible mechanisms involved.

show abstract

Psoriasis and risk of celiac disease: A systematic review and meta-analysis

Cited by 47 publications

References 20 publications

Celiac disease and risk of sarcoidosis: A systematic review and meta‐analysis

Celiac disease and risk of sarcoidosis: A systematic review and meta‐analysis

HLA-Cw6 and psoriasis

Cutaneous and Mucosal Manifestations Associated to Celiac Disease

Contact Info

Product

Resources

About