Pseudoporphyria induced by voriconazole

Sharp, Misty T.; Horn, Thomas

doi:10.1016/j.jaad.2005.03.030

Cited by 47 publications

(21 citation statements)

References 56 publications

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“…Reported dermatological side effects include urticaria, Stevens‐Johnson Syndrome, toxic epidermal necrolysis, discoid lupus erythematosus, chelitis and allergic infusion reactions. Two cases of pseudoporphyria secondary to voriconazole have been reported, in one case the timing of the lesions occurred in association with the intermittent use of this antifungal agent (1). To date, no further unpublished cases of pseudoporphyria secondary to voriconazole have been reported (information from Pfizer Limited).…”

Section: Discussionmentioning

confidence: 99%

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Voriconazole‐induced pseudoporphyria

Tolland

McKeown

Corbett

2007

Photoderm Photoimm Photomed

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Section: Discussionmentioning

confidence: 99%

“…We report a case of pseudoporphyria secondary to the new triazole antifungal medication, voriconazole. To date only two cases of pseudoporphyria secondary to voriconazole have been reported in the literature (1, 2).…”

mentioning

confidence: 99%

Voriconazole‐induced pseudoporphyria

Tolland

McKeown

Corbett

2007

Photoderm Photoimm Photomed

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“…It has sometimes been attributed to voriconazole [25][26][27][28] ; in one case it was controlled with a sunscreen during continued voriconazole exposure. 29 However, phototoxic reactions due to voriconazole can also be associated with true porphyria cutanea tarda, with superficial cheilitis.…”

Section: Mechanisms and Susceptibility Factorsmentioning

confidence: 99%

Photosensitivity reactions and skin tumours associated with voriconazole

Aronson¹

2015

Adverse Drug Reaction Bulletin

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Use of voriconazole, a triazole antifungal drug, has often been associated with photosensitivity, and this adverse reaction has been linked to a risk of tumours in light-exposed areas, especially squamous cell carcinomas, but also melanomas. The mechanisms by which voriconazole causes these effects are not clear, but susceptibility factors for a predisposition to skin cancers include duration of use, immunosuppression, ultraviolet (UV) exposure, advanced age, and skin type. Voriconazole should be used carefully, particularly in patients with susceptibility factors for skin cancer. If prolonged voriconazole therapy is required, it is advisable to have frequent diligent skin examinations, to avoid excess sunlight, and to use UV protectants liberally.

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“…Pseudoporphyria is most commonly attributable to naproxen [54] , nalidixic acid [55] , vorconazole [56] , tetracyclines [57] , furosemide [58] , pyridoxine [59] and NSAIDs [60] . Naproxen, a priopionic acid derivative, also a cause of photoallergy, is likely the most common cause of drug-induced pseudoporphyria [61] .…”

Section: Drug-induced Pseudoporphyriamentioning

confidence: 99%

Drug-induced phototoxicity evoked by inhibition of human ABC transporter ABCG2: development ofin vitrohigh-speed screening systems

Tamura

Hagiya

et al. 2008

Expert Opinion on Drug Metabolism & Toxicology

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Background : Photosensitivity depends on both genetic and environmental factors. Pheophorbide a, present in various plant-derived foods and food supplements, can be absorbed by the small intestine. Accumulation of pheophorbide a and porphyrins in the systemic blood circulation can result in phototoxic lesions on light-exposed skin. Objective : As the human ATP-binding cassette (ABC) transporter ABCG2 has been suggested to be critically involved in porphyrin-mediated photosensitivity, we aimed to develop in vitro screening systems for drug-induced phototoxicity. Conclusion : Functional impairment owing to inhibition of ABCG2 by drugs or its genetic polymorphisms can lead to the disruption of porphyrin homeostasis. This review article provides an overview on drug-induced photosensitivity, as well as our hypothesis on a potential role of ABCG2 in phototoxicity.

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Pseudoporphyria induced by voriconazole

Cited by 47 publications

References 56 publications

Voriconazole‐induced pseudoporphyria

Voriconazole‐induced pseudoporphyria

Photosensitivity reactions and skin tumours associated with voriconazole

Drug-induced phototoxicity evoked by inhibition of human ABC transporter ABCG2: development ofin vitrohigh-speed screening systems

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