Pseudoporphyria Induced by Oral Contraceptive Pills

Pseudoporphyria induced by voriconazole

“…This may be difficult as it has been well reported that blisters may continue to appear for weeks or months after discontinuation of the presumed offending drug. 14,15,48 This fact is also illustrated in our patient. Patients in whom pseudoporphyria develops should also be advised to apply broad-spectrum sunscreens and sun-protective clothing for several months after drug cessation.…”

“…Pseudoporphyria mimics PCT clinically with vesicles, bullae, skin fragility, milia, and scarring on sun-exposed skin. 1,48 However, the hypertrichosis, hyperpigmentation, sclerodermoid changes, and dystrophic calcification associated with PCT are rarely seen. 49 Histologically, pseudoporphyria also resembles PCT with pauci-inflammatory subepidermal bullae with or without festooning of dermal papillae and scant to mild lymphocytic perivascular infiltrate.…”

Does hormone replacement therapy and use of oral contraceptives increase the risk of non-melanoma skin cancer?

“…Several hypotheses may explain how use of HRT/OC can act in conjunction with several known pathways in the NMSC carcinogenesis. Estrogens are known to be photosensitizing drugs than can affect the skins' UV sensitivity [35][36][37]. UV-induced DNA damage in the skin, which eventually can promote NMSC carcinogenesis, is normally prevented by the skins' ability to repair damaged DNA.…”

Oral Contraceptives: A Risk Factor for Squamous Cell Carcinoma?

“…Unlike these other cancers, the relationship between NMSC and oral contraceptives (OCs) has not been thoroughly examined. Yet, OCs affect the skin, including acting as a photosensitizing agent by potentiating the skin's reaction to UV radiation, the dominant risk factor for NMSC (Esoda, 1963; Satterthwaite, 1964; Resnik, 1967; Mathison and Haas, 1970; Horkay et al , 1975; Sedee and Beijersbergen van Henegouwen, 1985; Diffey, 1986; Neumann, 1988; Cooper and George, 2001; Silver et al , 2003). Estrogens, as growth-promoting hormones, could enhance the risk of NMSC (Preston-Martin et al , 1990; Williams et al , 1991).…”