Pseudoneoplastic Appearance of Cytomegalovirus-Associated Colitis in Nonimmunocompromised Patients: Report of 2 Cases

Abstract

Two cases of human cytomegalovirus (HCMV) colitis with pseudoneoplastic appearance are described. Patients presented with abdominal pain, fever, and diarrhea. Colonoscopy revealed a stenosing lesion in one patient and a broad-based, vegetant mass in the other patient, and histopathological examination of colectomy specimens revealed exuberant inflammatory masses with infiltration of mononuclear cells and ulcers with granulation tissue. Typical intranuclear HCMV inclusions were numerous. Peculiar to both patients was the lack of any apparent causes of immunodeficiency, such as human immunodeficiency virus infection or previous organ transplantation.

Rectosigmoid Inflammatory Cytomegalovirus Pseudotumor: A Disappearing Act

“…CMV associated with pseudotumor development, however, has only been reported in eleven patients in the medical literature, with only three reported as being immunocompetent [5][6][7][8][9]. Two of these patients manifested typical symptoms of colitis whereas the third initially complained of right lower quadrant pain for 4 days.…”

Perforated cytomegalovirus pseudotumour

“…Treatment of CMV infection in the gastrointestinal tract is well described; however, response and success with antiviral therapy for pseudotumours is limited to case reports . Unfortunately, perhaps due to the extent and severity of the disease it was unsuccessful in our patient.…”

Cytomegalovirus colitis mimicking rectal carcinoma in an immunocompetent elderly woman

“…Colonic masses secondary to CMV infection are extremely rare in the literature, and almost all cases have been reported in elderly patients. [5][6][7][8][9][10] However, there has been no study about the presentation and clinical course of colonic CMV virus infections in the elderly population.…”

“…In addition, serum vitamin B 1 , whose deficiency might have an affect on the development of PD, should be evaluated in such cases. 6 In conclusion, parkinsonism and cognitive impairment might be due to vitamin B 12 deficiency only. Therefore, before PD diagnosis, and levodopa treatment, clinicians should absolutely evaluate serum vitamin B 12 levels, and adequate supplement therapy should be implemented in these patients.…”