Pseudomonas botryomycosis

Abstract

A patient had cutaneous botryomycosis due to Pseudomonas aeruginosa. The diagnosis of botryomycosis was based on the clinical manifestations, results of bacterial culture, and demonstraction of the Gram-negative organisms by tissue Gram stain of the granules in the dermis and subcutaneous fat. Numerous laboratory tests, including tissue immunofluorescence and special studies with the patient's lymphocytes, failed to demonstrate an abnormality that might help to explain the pathogenesis of the granular tissue reaction in this patient.

ReviewCutaneous manifestations due toPseudomonasinfection

“…PA can also cause blastomycosis‐like pyoderma. 25 The lesions are large verrucous plaques with multiple pustules and elevated borders. Histologic study reveals pseudoepitheliomatous hyperplasia with abscesses, but without giant cells or fungal organisms.…”

Malignant Mimickers: Chronic Bacterial and Fungal Infections of the Larynx

“…"Botryo," which means grape-like or granular, and "mycosis," which refers to the once-believed fungal origin, give this condition somewhat of a misnomer. [8][9][10][11] This is a chronic suppurative and granulomatous process caused by Staphylococcus aureus or occasionally gram-negative organisms, such as Proteus mirabilis or Pseudomonas aeruginosa. It is typically preceded by a traumatic event, often in diabetic patients, and can occur as a soft tissue or visceral condition.…”

“…In this case, the granules were not encountered; however, the presentation, the indolent course of disease, the presumed traumatic pathogenesis, the question of underlying diabetes, and the response to surgical debulking and antibiotic therapy support a diagnosis of botryomycosis. [8][9][10][11] Nocardia is found worldwide in the soil and infects humans via the respiratory tract or after dental injury. 1,3,4 The initial pulmonary focus is poorly encapsulated, accounting for the relatively frequent dissemination of this bacteria.…”

Botryomycosis of the oral cavity

“…Magrou emphasized the importance of staphylococci as a pathogen. Yet many other pathogens have been identified including Pseudomonas aeruginosa, 11,16 proteus,l microaerophilic streptoc~cci,'~ and coagulase negative staphylococci." Mixed oral flora was isolated from the oral lesion described by Small and Kobernick' and included Neisseria catarrhalis, alpha streptococcus, non-group A beta hemolytic streptococcus, alpha streptococcus, diptheroids, Veionella, and staphylococcus albus.'…”