Pseudomonas aeruginosa hijacks the murine nitric oxide metabolic pathway to evade killing by neutrophils in the lung

Nakatsuka, Yoshinari; Matsumoto, Masanori; Inohara, Naohiro; Núñez, Gabriel

doi:10.1016/j.celrep.2023.112973

Cited by 2 publications

(1 citation statement)

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“…Phagocytes kill bacteria by releasing ROS in the respiratory burst, but they also secrete RNS, including nitric oxide ( • NO) generated from inducible nitric oxide synthase (iNOS). Bacteria can be exposed to ROS and/or • NO inside the phagosome and killed through the generation of oxidative and/or nitroxidative* activity (Nakatsuka et al 2023 ) (*term per; Lancaster 2006 ). • NO also has the potential of being converted to other antimicrobial RNS, such as nitrate or nitrite.…”

Section: Gbs Evasion Of Host Defencesmentioning

confidence: 99%

An opportunistic pathogen under stress: how Group B Streptococcus responds to cytotoxic reactive species and conditions of metal ion imbalance to survive

Goh,

Desai,

Thapa

et al. 2024

FEMS Microbiology Reviews

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Group B Streptococcus (GBS; also known as Streptococcus agalactiae) is an opportunistic bacterial pathogen that causes sepsis, meningitis, pneumonia and skin and soft tissue infections in neonates and healthy or immunocompromised adults. GBS is well-adapted to survive in humans due to a plethora of virulence mechanisms that afford responses to support bacterial survival in dynamic host environments. These mechanisms and responses include counteraction of cell death from exposure to excess metal ions that can cause mismetallation and cytotoxicity, and strategies to combat molecules such as reactive oxygen and nitrogen species that are generated as part of innate host defence. Cytotoxicity from reactive molecules can stem from damage to proteins, DNA, and membrane lipids, potentially leading to bacterial cell death inside phagocytic cells or within extracellular spaces within the host. Deciphering the ways in which GBS responds to the stress of cytotoxic reactive molecules within the host will benefit the development of novel therapeutic and preventative strategies to manage the burden of GBS disease. This review summarises knowledge of GBS carriage in humans and the mechanisms used by the bacteria to circumvent killing by these important elements of host immune defence: oxidative stress, nitrosative stress, and stress from metal ion intoxication/mismetallation.

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Section: Gbs Evasion Of Host Defencesmentioning

confidence: 99%