Pseudomonas aeruginosa blepharoconjunctivitis during cytoreductive chemotherapy in a woman with acute lymphocytic leukemia

Giagounidis, Aristoteles; Meckenstock, G.; Flacke, Sebastian; Burk, M.; Wehmeier, A.; Aul, C.; Schneider, Wolfgang

doi:10.1007/s002770050325

Cited by 15 publications

(12 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This infection may occasionally start as a blepharoconjunctivitis and spread to cause orbital cellulitis. 65 It is important to Ophthalmic manifestations of acute leukaemias T Sharma et al…”

Section: Opportunistic Infectionsmentioning

confidence: 99%

Ophthalmic manifestations of acute leukaemias: the ophthalmologist's role

Sharma

Grewal

Gupta

et al. 2004

Eye

206

166

View full text Add to dashboard Cite

With evolving diagnostic and therapeutic advances, the survival of patients with acute leukaemia has considerably improved. This has led to an increase in the variability of ocular presentations in the form of side effects of the treatment and the ways leukaemic relapses are being first identified as an ocular presentation. Leukaemia may involve many ocular tissues either by direct infiltration, haemorrhage, ischaemia, or toxicity due to various chemotherapeutic agents. Ocular involvement may also be seen in graft-versushost reaction in patients undergoing allogeneic bone marrow transplantation, or simply as increased susceptibility to infections as a result of immunosuppression that these patients undergo. This can range from simple bacterial conjunctivitis to an endophthalmitis. Leukaemia can present as pathology in the adnexae, conjunctiva, sclera, cornea, anterior chamber, iris, lens, vitreous, retina, choroid, and optic nerve. Recognition of the varied ocular presentations is also important in assessing the course and prognosis of leukaemia. We have presented a systematic approach taking each part of the eye in turn and outlining how leukaemia has been shown to affect it.

show abstract

Section: Opportunistic Infectionsmentioning

confidence: 99%

Ophthalmic manifestations of acute leukaemias: the ophthalmologist's role

Sharma

Grewal

Gupta

et al. 2004

Eye

206

166

View full text Add to dashboard Cite

show abstract

“…In particular, immunocompromised or immunosuppressed states as a consequence of immune incapacitating disease processes or the use of medications, such as immunosuppressants or chemotherapy, increase the risk of acquiring infections [9], and hence, conjunctivitis. In addition, chemotherapy agents themselves, such as cytosine arabinoside, may be irritating to the conjunctiva based on the drug concentration present in tears [10].…”

Section: Discussionmentioning

confidence: 99%

A Case of Chronic Conjunctivitis following Rituximab Therapy

Quan

Wang

2009

Advances in Hematology

View full text Add to dashboard Cite

The activity of the anti-CD20 monoclonal antibody, rituximab in B-cell non-Hodgkin's lymphoma, with relatively minimal toxicity has been well established. Adverse effects such as low-grade fever, urticaria, bronchospasm, sporadic tachycardia, and hypotension have been described. However, only a single case of rituximab-related, transient conjunctivitis has been documented in literature. We report an occurrence of chronic, bilateral conjunctivitis in an 88-year-old female diagnosed with stage IV, non-Hodgkin's lymphoma (NHL), who was maintained on rituximab for 12 months. In contrast to the previously described case, our patient developed severe conjunctival inflammation approximately three to four weeks following rituximab induction. Resolution of conjunctivitis occurred within two months after cessation of rituximab treatment.

show abstract

“…In this case, the patient finishing immunosuppressive chemotherapy should be aggressively treated if such an infection is suspected. Although P. aeruginosa is an exceptionally rare cause of periorbital necrotizing fasciitis, with only one other case report mentioned in the literature, 10 it should be considered in the case of the immunocompromised patient. Furthermore, P. aeruginosa is more common as a causative agent in cases of dacryocystitis, with studies isolating this organism in 5.3 to 8.7 percent of dacryocystitis cases.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11] Most of these reported infections have been associated with immunosuppressive disorders, alcoholism, polymyositis, trauma, or postsurgical exposure. [3][4][5][6][7][8][9][10][11][12] Etiologically, periorbital necrotizing fasciitis can be an aerobic, anaerobic, or polymicrobial infection, with the vast majority of bacteria isolates being group A ␤-hemolytic streptococci and/or Staphylococcus aureus. [1][2][3] There has been one case report each of Enterobacter diversus, Streptococcus viridans, Cryptococcus neoformans, and Pseudomonas aeruginosa causing periorbital necrotizing fasciitis.…”

mentioning

confidence: 99%