Pseudogene HSPA7 is a poor prognostic biomarker in Kidney Renal Clear Cell Carcinoma (KIRC) and correlated with immune infiltrates

Abstract

Background Pseudogenes played important roles in tumorigenesis, while there are nearly no reports about the expression and roles of HSPA7 in the cancer. Methods Firstly, we used Logistic regression, the KS test, the GEPIA database, UALCAN database and qRT-PCR to analyze the expression level of HSPA7 in KIRC, then we used the Cox regression and the Kaplan–Meier curve to analyze the overall survival (OS) of KIRC patients with different Clinico-pathological parameters. Thirdly, we used the multivariate Cox analysis of influencing factors to compare the correlation between the HSPA7 expression level and the clinical parameters. Finally, we used multi-GSEA analysis and the Tumor Immunoassay Resource (TIMER) database to explore the functional role of HSPA7 in KIRC Results The HSPA7 is highly expressed in KIRC tumor tissues, and its expression is related to clinico-pathological features and survival in KIRC patients. GSEA analysis displayed the high expression of HSPA7 in KIRC were related to several tumor-related and immune-related pathways. With the TIMER database analysis we showed that HSPA7 levels were correlated with the CD4+ T cells, neutrophils and Dendritic Cell. Conclusions Our study showed that HSPA7 is very important in the tumor progression and may act as a poor prognostic biomarker for KIRC tumor by modulating immune infiltrating cells.

The RPL4P4 Pseudogene Is a Prognostic Biomarker and Is Associated with Immune Infiltration in Glioma

“…In recent years, the roles of pseudogenes have been reported to be associated with various human diseases, including cancer, and have attracted much attention [ 22 ]. Several pseudogenes are differentially expressed in glioma tissues and are implicated in biological processes related to tumorigenesis and drug resistance to chemotherapy [ 23 , 24 ].…”

“…Further advancements in technologies that identify new biomarkers to improve the understanding of the regulation of cell processes and treatment of glioma are needed. In recent years, the roles of pseudogenes have been reported to be associated with various human diseases, including cancer, and have attracted much attention [22]. Several pseudogenes are differentially expressed in glioma tissues and are implicated in biological processes related to tumorigenesis and drug resistance to chemotherapy [23,24].…”

Pan-Cancer Analysis of the N6-Methyladenosine Eraser FTO as a Potential Prognostic and Immunological Biomarker

“…Hence, aberrant FTO expression, which is highly related to MMR deficiency, MSI, TMB, and DNA methyltransferases, may be a hopeful tumor biomarker used to select patients for the immune treatment. Taken together, compared with reported biomarkers, such as eEF2K, 47 NTRK3, 48 and HSPA7, 49 which predict the prognosis of a single cancer, FTO may serve as a prognostic and immune biomarker for more cancers. However, further experiments are needed to confirm these findings.…”

Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells

“…Moreover, CPT1A plays a crucial role in radioresistant and chemoresistant phenotypes in diverse cancer types [ 41 , 42 , 82 ]. Equally, altered protein levels of FLNA, HSPA7, HGF, ERO1A, and GARS1, have been related to cancer migration, adhesion, poor patient prognosis, and metastasis [ 48 , 49 , 50 , 83 , 84 ]. Particularly, filamin A (FLNA), a cytoskeleton regulator, has been reported as taking on opposite roles depending on the cancer type [ 47 ].…”