Pseudoexfoliation of the Lens Capsule and Liberation of Iris Pigment

Abstract

A total of 220 inmates of old people's homes, all over 60 years of age, were examined for pseudoexfoliation of the lens capsule. The incidence recorded for the age group 60-69 years was 10°/o, 70-79 years 21.3O/o and 80-89 years 32.8 "/a. The intraocular tension of the eyes with pseudoexfoliation averaged 17.5 mmHg, against an average of 15.4 mmHg in normal eyes. After mydriatics, pigmented floaters were seen in the aqueous humour of 61.5 O / o of the normal eyes, and 83.3 "/o of the eyes with pseudoexfoliation. In these latter eyes, moreover, the pigment liberation was distinctly more marked. The trabecular region of the affected eyes was more pigmented than that of the normal eyes. The mechanism by which pseudoexfoliation possibly affects pigment liberation and trabecular pigmentation is discussed.

Cataract and Pseudoexfoliation

“…The results are presented in Table I1 exfoliation was established in 26.7 010 of the lowest age group, 50-59 years, in 33.3 010 of the age group 60-69 years, 29.7 010 70-79 years, and in 50.0 010 on the patients over 80 years. The small number of lenses in each group did not warrant statistical treatment, but the tendency towards a rising frequency with age was similar to the findings in other clinical reports (Aasved 1971b;Krause et al 1973). Pseudoexfoliation was encountered clinically and histologically in 16 cases.…”

Cataract and Pseudoexfoliation

“…The results are presented in Table I1 exfoliation was established in 26.7 010 of the lowest age group, 50-59 years, in 33.3 010 of the age group 60-69 years, 29.7 010 70-79 years, and in 50.0 010 on the patients over 80 years. The small number of lenses in each group did not warrant statistical treatment, but the tendency towards a rising frequency with age was similar to the findings in other clinical reports (Aasved 1971b;Krause et al 1973). Pseudoexfoliation was encountered clinically and histologically in 16 cases.…”

The Cyclopentolate Provocative Test in Suspected or Untreated Open‐angle Glaucoma

“…Liberation of pigment during C P T was statistically highly significantly (P < 0.001) more profuse in eyes with pseudoexfoliation than in eyes without pseudoexfoliation (Table 111). T h e same observation was made by Krause et al (1973). Pigment liberation in the aqueousthough distinctly more infrequently and a smaller degreewas seen also in eyes without pseudoexfoliation.…”

“…Pigment was liberated in the aqueous during CPT in 31.90/0 (Table 11). This is a higher frequency than the figure reported by Mitsui & Takagi (1961) for persons healthy in regard to glaucoma, but distinctly lower than the frequency obtained in other earlier studies using sympathomimetics (Kristensen 1965(Kristensen , 1968Haddad et al 1970) or sympathomimetics and parasympatholytics as the mydriatic agent (Krause et al 1973). Mitsui & Takagi (1961) reported considerably less frequent and less profuse liberation of pigment with parasympatholytics than with 5 o/o phenylephrine.…”

Pigmentation of the anterior chamber angle in normal and pseudoexfoliative eyes

“…Krause et al (1973) found the IOP to be higher in eyes with PEX when compared to PEX-negative eyes, similar results were obtained by Madden & Crowley (1982). Krause et al (1973) reported increased liberation of iris pigment in PEX-positive eyes implying that this might lead to trabecular blockage. Similar results were reported by Mapstone (1981).…”

Cataract and Pseudoexfoliation

“…The results are presented in Table I1 exfoliation was established in 26.7 010 of the lowest age group, 50-59 years, in 33.3 010 of the age group 60-69 years, 29.7 010 70-79 years, and in 50.0 010 on the patients over 80 years. The small number of lenses in each group did not warrant statistical treatment, but the tendency towards a rising frequency with age was similar to the findings in other clinical reports (Aasved 1971b;Krause et al 1973). Pseudoexfoliation was encountered clinically and histologically in 16 cases.…”

The Cyclopentolate Provocative Test in Suspected or Untreated Open‐angle Glaucoma

“…Liberation of pigment during C P T was statistically highly significantly (P < 0.001) more profuse in eyes with pseudoexfoliation than in eyes without pseudoexfoliation (Table 111). T h e same observation was made by Krause et al (1973). Pigment liberation in the aqueousthough distinctly more infrequently and a smaller degreewas seen also in eyes without pseudoexfoliation.…”

“…Pigment was liberated in the aqueous during CPT in 31.90/0 (Table 11). This is a higher frequency than the figure reported by Mitsui & Takagi (1961) for persons healthy in regard to glaucoma, but distinctly lower than the frequency obtained in other earlier studies using sympathomimetics (Kristensen 1965(Kristensen , 1968Haddad et al 1970) or sympathomimetics and parasympatholytics as the mydriatic agent (Krause et al 1973). Mitsui & Takagi (1961) reported considerably less frequent and less profuse liberation of pigment with parasympatholytics than with 5 o/o phenylephrine.…”

Pigmentation of the anterior chamber angle in normal and pseudoexfoliative eyes

“…Krause et al (1973) found the IOP to be higher in eyes with PEX when compared to PEX-negative eyes, similar results were obtained by Madden & Crowley (1982). Krause et al (1973) reported increased liberation of iris pigment in PEX-positive eyes implying that this might lead to trabecular blockage. Similar results were reported by Mapstone (1981).…”

Cataract and Pseudoexfoliation

“…The results are presented in Table I1 exfoliation was established in 26.7 010 of the lowest age group, 50-59 years, in 33.3 010 of the age group 60-69 years, 29.7 010 70-79 years, and in 50.0 010 on the patients over 80 years. The small number of lenses in each group did not warrant statistical treatment, but the tendency towards a rising frequency with age was similar to the findings in other clinical reports (Aasved 1971b;Krause et al 1973). Pseudoexfoliation was encountered clinically and histologically in 16 cases.…”

The Cyclopentolate Provocative Test in Suspected or Untreated Open‐angle Glaucoma

“…Liberation of pigment during C P T was statistically highly significantly (P < 0.001) more profuse in eyes with pseudoexfoliation than in eyes without pseudoexfoliation (Table 111). T h e same observation was made by Krause et al (1973). Pigment liberation in the aqueousthough distinctly more infrequently and a smaller degreewas seen also in eyes without pseudoexfoliation.…”

“…Pigment was liberated in the aqueous during CPT in 31.90/0 (Table 11). This is a higher frequency than the figure reported by Mitsui & Takagi (1961) for persons healthy in regard to glaucoma, but distinctly lower than the frequency obtained in other earlier studies using sympathomimetics (Kristensen 1965(Kristensen , 1968Haddad et al 1970) or sympathomimetics and parasympatholytics as the mydriatic agent (Krause et al 1973). Mitsui & Takagi (1961) reported considerably less frequent and less profuse liberation of pigment with parasympatholytics than with 5 o/o phenylephrine.…”

Pigmentation of the anterior chamber angle in normal and pseudoexfoliative eyes

“…Krause et al (1973) found the IOP to be higher in eyes with PEX when compared to PEX-negative eyes, similar results were obtained by Madden & Crowley (1982). Krause et al (1973) reported increased liberation of iris pigment in PEX-positive eyes implying that this might lead to trabecular blockage. Similar results were reported by Mapstone (1981).…”