Mircea Balasa, Didac Vidal-Piñeiro, Albert Lladó, Anna Antonell, Beatriz Bosch, Fernando Castellanos, Nuria Bargalló, David Bartres-Faz, José-Luis Molinuevo, Raquel Sánchez-Valle
Abstract:Most cases of early-onset Alzheimer's disease (EOAD) are sporadic. A minority of EOAD are caused by specific genetic defects in PSEN1, PSEN2, or AβPP genes. Magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) biomarker comparisons between sporadic and monogenic EOAD are practically inexistent. CSF and MRI data from 14 amnestic-onset sporadic EOAD (sEOAD) subjects were compared with data from 8 symptomatic PSEN1 mutation carriers (PSEN1) and 14 age-matched cognitively-preserved controls. CSF concentr…
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