Przedposiłkowe i poposiłkowe zmiany stężeń obu form greliny u osób otyłych i nieotyłych

Dardzińska, Jolanta Anna; Małgorzewicz, Sylwia; Kaska, Łukasz; Proczko, Monika; Stefaniak, Tomasz; Stankiewicz, Marta; Śledziński, Zbigniew

doi:10.5603/ep.2014.0052

Cited by 16 publications

(5 citation statements)

References 22 publications

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“…Our findings are in line with previous studies exhibiting that total plasma ghrelin was lower in individuals with both hypertension and obesity in comparison to those obese or healthy control ( 19 ). According to our data, the decrease in total ghrelin of centrally obese, hypertensive women was largely accounted by the reduction of UnAG, which is the predominant form of circulatory ghrelin ( 34 ). Only main effect of hypertension was observed on AG, suggesting that hypertension is sufficient to reduce the level of AG, regardless of the presentation of central obesity.…”

Section: Discussionmentioning

confidence: 58%

Ghrelin Axis Reveals the Interacting Influence of Central Obesity and Hypertension

Ugwu

Tam

et al. 2018

Front. Endocrinol.

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Objective: This study aimed to investigate how central obesity and hypertension modulate unacylated ghrelin (UnAG), acylated ghrelin (AG), obestatin, growth hormone (GH), and the ratios of UnAG/obestatin, AG/obestatin, and total ghrelin/obestatin.Methods: Circulatory abundances of UnAG, AG, obestatin and GH were determined in 387 Hong Kong Chinese female adults with age between 24 to 86 years based on a 2 × 2 factorial design of hypertension (blood pressure ≥140/90 mmHg) and central obesity (waist circumference or WC ≥80 cm). Participants were categorized as neither hypertensive nor centrally obese (NHNO; n = 105), hypertensive but not centrally obese (HNO; n = 102), centrally obese but not hypertensive (NHO; n = 74) and hypertensive and centrally obese (NO; n = 106). Pearson's correlation analyses were performed to detect the association between the peptides examined with WC and blood pressure. The main and interaction effects of hypertension and central obesity were examined by generalized estimating equations analyses.Results: Correlation analyses revealed that systolic blood pressure was negatively correlated with AG/obestatin, UnAG/obestatin and total ghrelin/obestatin ratios, AG, total ghrelin, and GH, while diastolic blood pressure was negatively correlated with UnAG/obestatin, total ghrelin/obestatin ratios, and GH. WC was negatively correlated with AG/obestatin, UnAG/obestatin, and total ghrelin/obestatin ratios, UnAG, AG, total ghrelin, GH, and obestatin. Interaction effects of hypertension and central obesity were observed on UnAG/obestatin, AG/obestatin and total ghrelin/obestatin ratios, and obestatin. Obestatin in NHO group was significantly higher compared to NHNO and HO groups. UnAG/obestatin, AG/obestatin, and total ghrelin/obestatin ratios were higher in NHNO group compared to HNO and HO groups. Main effects of central obesity and hypertension were observed in UnAG, total ghrelin and GH. The HO group manifested the lowest level of UnAG, total ghrelin and GH among all the groups studied. Main effect of hypertension was observed on AG, suggesting that hypertensive individuals exhibited lower levels of AG regardless of central obesity.Conclusion: Circulatory ghrelin gene products and GH exhibit different modes of modulation in response to the co-manifestation of multiple cardiovascular risk factors compared with a single risk factor alone.

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Section: Discussionmentioning

confidence: 58%

Ghrelin Axis Reveals the Interacting Influence of Central Obesity and Hypertension

Ugwu

Tam

et al. 2018

Front. Endocrinol.

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“…It was reported by Barazzoni that obese people with metabolic syndrome have a higher acyl/desacyl ratio [ 7 ]. However, in our earlier study we found the opposite – the fasting AG/DAG ratio was significantly higher in non-obese controls than in obese non-diabetic patients [ 6 ]. In spite of those discrepancies, it is not explained how bariatric procedures modulate the AG/DAG ratio [ 23 ].…”

Section: Discussionmentioning

confidence: 78%

“…The MGB procedure appeared to reduce fasting acyl ghrelin levels and provided effective weight reduction in those patients. Prader-Willi syndrome is known to be characterized by the presence of hyperghrelinemia, and simple obesity is associated with reduced ghrelin levels [ 2 , 6 ]. According to available data we demonstrated for the first time that levels of both ghrelin isoforms (in the fasting state as well as prandial) did not change in a year of observation after MGB.…”

Section: Discussionmentioning

confidence: 99%

“…The interactions between both isoforms may be important in the energy balance [ 3 , 4 ]. It is also important to assess the fasting as well as postprandial level of both ghrelin isoforms, because they are obviously affected by food intake and their proportions can be changed in obesity [ 5 , 6 ]. There are suggestions that obese people with metabolic syndrome have a higher acyl/desacyl ratio (AG/DAG) [ 7 ] and that this ratio may be modulated by some form of medical intervention [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Fasting and postprandial acyl and desacyl ghrelin and the acyl/desacyl ratio in obese patients before and after different types of bariatric surgery.

Dardzińska¹,

Kaska²,

Proczko-Stepaniak³

et al. 2018

Videosurgery and Other Miniinvasive Techniques

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IntroductionThe mechanism underlying beneficial outcomes of bariatric surgery still remains unclear. Especially little is known about hormonal and metabolic changes induced by the novel bariatric procedure mini gastric bypass (MGB).AimTo evaluate pre- and post-prandial changes in both ghrelin isoforms in obese patients without diabetes and cardiovascular complications treated with MGB, sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) surgery.Material and methodsFrom 45 patients initially enrolled in the study, 23 persons completed a one-year follow-up period. Venous blood for acyl and desacyl ghrelin (AG and DAG) as well as other metabolic assays was collected 3 months before and 6 and 12 months after bariatric surgery (MGB, RYGB, SG) – in the fasting state and 2 h after the consumption of a standard 300 kcal-mixed meal (Nutridrink standard, Nutricia).ResultsAG and DAG levels (both fasting and prandial) as well as AG/DAG ratio did not change after 6 and 12 months in MGB and RYGB groups. In the SG group we observed a significant decrease in fasting and postprandial DAG levels and consecutively an increase in the fasting AG/DAG ratio after 6 and 12 months. Six months after surgery we observed some differences between carbohydrate metabolism measures in the MGB group (lower HbA1c, HOMA-IR and fasting insulinaemia) in comparison to the rest of the participants, but 12 months after each type of surgery body mass index and indices of carbohydrate and lipid metabolism did not differ.ConclusionsThe results of our study demonstrate that all studied bariatric procedures can successfully reduce overall body weight and suggest also that the mechanisms of weight loss and improvement in carbohydrate and lipid metabolism after all three types of surgery are independent of ghrelin and the acyl/desacyl ghrelin ratio.

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“…It has become increasingly recognized that UnAG plays crucial roles in metabolism. Fasting UnAG has been demonstrated to be significantly higher in normal healthy subjects when compared to individuals with MetS risk factor such as central obesity ( Dardzinska et al, 2014 ). In a 2-week clinical trial, single daily injection of AZP-531, an UnAG agonist, decreased body weight from baseline in obese subjects ( Allas et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

One Year of Yoga Training Alters Ghrelin Axis in Centrally Obese Adults With Metabolic Syndrome

Ugwu

Tam

et al. 2018

Front. Physiol.

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Introduction: Metabolic syndrome (MetS) is a multiplex cardiometabolic manifestation associated with type 2 diabetes mellitus and cardiovascular diseases. Yoga training has been shown to alleviate MetS. Recently, circulatory ghrelin profile was demonstrated to be associated with MetS. This study examined the effects of 1 year of yoga training on β-cell function and insulin resistance, and the involvement of metabolic peptides, including unacylated ghrelin (UnAG), acylated ghrelin (AG), obestatin, growth hormone (GH), and insulin, in the beneficial effects of yoga training in centrally obese adults with MetS.Methods: This was a follow up study, in which data of risk factors of MetS, physical performance tests [resting heart rate (HR), chair stand test (CS), chair sit and reach test (CSR), back scratch test (BS), and single leg stand tests (SLS)] and serum samples of 79 centrally obese MetS subjects aged 58 ± 8 years (39 subjects received 1-year yoga training and 40 subjects received no training) were retrieved for analyses. β-cell function and insulin resistance were examined by Homeostasis Model Assessment (HOMA). Circulating levels of UnAG, AG, obestatin, GH, and insulin were determined by enzyme-linked immunosorbent assay using fasting serum samples. Generalized estimating equation analysis and Mann–Whitney U-test were used to detect statistically significant differences between groups.Results: Waist circumference (WC) was significantly decreased after yoga intervention (control: +2%; yoga: -4%). Significant improvements in HR (control: +2%; yoga: -5%), CS (control: -1%; yoga: +24%), CSR left (control: worsen by 0.90 cm; yoga: improved by 4.21 cm), CSR right (control: worsen by 0.75 cm; yoga: improved by 4.28 cm), right side of BS (control: improved by 0.19 cm; yoga: improved by 4.31 cm), SLS left (control: -10%; yoga: +86%), and SLS right (control: -6%; yoga: +47%) were observed after 1-year yoga training. No significant difference was found between the two groups in insulin, HOMA indices, and disposition index. Yoga training significantly increased circulating GH (control: -3%; yoga: +22%), total circulating ghrelin (control: -26%; yoga: +13%), and UnAG (control: -27%; yoga: +14%), whereas decreased AG (control: -7%; yoga: -33%) and obestatin (control: +24%; yoga: -29%).Conclusion: One-year of yoga training modulated total ghrelin, UnAG, AG, obestatin, and GH while exerting beneficial effects on physical functions and central obesity in adults with MetS. The beneficial effects of yoga may be associated with the alteration of ghrelin gene product and GH.

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Przedposiłkowe i poposiłkowe zmiany stężeń obu form greliny u osób otyłych i nieotyłych

Cited by 16 publications

References 22 publications

Ghrelin Axis Reveals the Interacting Influence of Central Obesity and Hypertension

Ghrelin Axis Reveals the Interacting Influence of Central Obesity and Hypertension

Fasting and postprandial acyl and desacyl ghrelin and the acyl/desacyl ratio in obese patients before and after different types of bariatric surgery.

One Year of Yoga Training Alters Ghrelin Axis in Centrally Obese Adults With Metabolic Syndrome

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