Prussian blue nanoparticle-based antigenicity and adjuvanticity trigger robust antitumor immune responses against neuroblastoma

Cano‐Mejia, Juliana; Bookstaver, Michelle L.; Sweeney, Elizabeth E.; Jewell, Christopher M.; Fernandes, Rohan

doi:10.1039/c8bm01553h

Cited by 41 publications

(45 citation statements)

References 50 publications

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“…Between 1.9 and 1.3 V, the device demonstrates almost identical transmittance spectra with a deep blue color. The near 0% transmittance in 600–800 nm can be attributed to the intrinsic absorption of PB layers caused by the metal‐to‐metal charge transfer between Fe and Fe through the cyanide bridge . At 1.3–0.7 V, the device's transmittance gradually increases with a decrease in discharge voltage, because of occurrence of the bleaching reaction (see Figure ).…”

Section: Resultsmentioning

confidence: 98%

A Long‐Life Battery‐Type Electrochromic Window with Remarkable Energy Storage Ability

et al. 2020

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Electrochromic (EC) windows with controllable transmittances according to ambient temperature and solar irradiation strength are highly desired for energy‐efficient buildings. However, traditional EC windows operate via consuming electrical energy to trigger the chromogenic reactions, with negligible energy storage ability. Herein, a facile battery‐type Prussian blue (PB, Fe4III[FeII(CN)6]3)/Zn EC window with excellent EC properties (transmittance modulation = 84.9% at 633 nm), remarkable energy storage ability (average output voltage = 1.24 V and areal capacity = 78.9 mAh m−2), fast switching time (tbleaching = 4.1 s and tcoloring = 4.6 s), as well as an ultralong cycling lifetime (7000 cycles with 60.7% capacity retention and 92.7% transmittance modulation retention) is reported, thanks to the rational electrode and electrolyte design. As an EC window, this device can effectively promote energy efficiency and occupational comfort of buildings by regulating visible light transmittance. As a battery, this device can work as backup power or a component of smart grids, making the buildings more sustainable and functional. The design concept of this bifunctional device is helpful to further the development of next‐generation EC windows.

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Section: Resultsmentioning

confidence: 98%

A Long‐Life Battery‐Type Electrochromic Window with Remarkable Energy Storage Ability

et al. 2020

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“…Similarly, PTT has been shown to trigger the thermal ablation‐induced tumor ICD and cause the release of tumor antigens and endogenous adjuvants (e.g., heat shock proteins and damaged‐associated molecular patterns) to stimulate the immune responses. [ 54,61 ] Our ICG‐PtMGs@HGd nanoparticles provided an O 2 self‐enriched nanoplatform for enhanced PDT/PTT, and might consequently enhance the synergistic phototherapy‐induced antitumor immune responses as the ICD caused by the phototherapy may trigger the maturation of dendritic cells and subsequently activated specific effector cells (e.g., CD8+ T cells, CD4+ T cells, macrophage polarization) to further inhibit the tumor growth and metastasis. [ 62 ] However, more efforts would be put on the functional studies to further elucidate the synergistic phototherapy‐mediated immune responses.…”

Section: Resultsmentioning

confidence: 99%

Persistent Regulation of Tumor Hypoxia Microenvironment via a Bioinspired Pt‐Based Oxygen Nanogenerator for Multimodal Imaging‐Guided Synergistic Phototherapy

et al. 2020

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Multifunctional nanoplatforms for imaging‐guided synergistic antitumor treatment are highly desirable in biomedical applications. However, anticancer treatment is largely affected by the pre‐existing hypoxic tumor microenvironment (TME), which not only causes the resistance of the tumors to photodynamic therapy (PDT), but also promotes tumorigenesis and tumor progression. Here, a continuous O2 self‐enriched nanoplatform is constructed for multimodal imaging‐guided synergistic phototherapy based on octahedral gold nanoshells (GNSs), which are constructed by a more facile and straightforward one‐step method using platinum (Pt) nanozyme‐decorated metal–organic frameworks (MOF) as the inner template. The Pt‐decorated MOF@GNSs (PtMGs) are further functionalized with human serum albumin‐chelated gadolinium (HSA‐Gd, HGd) and loaded with indocyanine green (ICG) (ICG‐PtMGs@HGd) to achieve a synergistic PDT/PTT effect and fluorescence (FL)/multispectral optoacoustic tomography (MSOT)/X‐ray computed tomography (CT)/magnetic resonance (MR) imaging. The Pt‐decorated nanoplatform endows remarkable catalase‐like behavior and facilitates the continuous decomposition of the endogenous H2O2 into O2 to enhance the PDT effect under hypoxic TME. HSA modification enhances the biocompatibility and tumor‐targeting ability of the nanocomposites. This TME‐responsive and O2 self‐supplement nanoparticle holds great potential as a multifunctional theranostic nanoplatform for the multimodal imaging‐guided synergistic phototherapy of solid tumors.

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“…Specifically, we utilize nanoparticle-based photothermal therapy (PTT), which causes light-activated thermal ablation of tumors [ 4 ]. PTT also elicits antitumor immune responses [ [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] ], and increasing evidence suggests that localized photothermal killing of a primary tumor ( via PTT) can induce immune-mediated regression in distant untreated tumors [ 5 , 13 ], a process termed as the abscopal effect [ [14] , [15] , [16] , [17] ]. While beneficial for treating disseminated cancer, the abscopal effects of PTT are often restricted by an immunosuppressive microenvironment within tumors [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

CpG-coated prussian blue nanoparticles-based photothermal therapy combined with anti-CTLA-4 immune checkpoint blockade triggers a robust abscopal effect against neuroblastoma

Cano‐Mejia

Shukla

Ledezma

et al. 2020

Translational Oncology

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High-risk neuroblastoma, which is associated with regional and systemic metastasis, is a leading cause of cancer-related mortality in children. Responding to this need for novel therapies for high-risk patients, we have developed a “nanoimmunotherapy,” which combines photothermal therapy (PTT) using CpG oligodeoxynucleotide-coated Prussian blue nanoparticles (CpG-PBNPs) combined with anti-CTLA-4 (aCTLA-4) immunotherapy. Our in vitro studies demonstrate that in addition to causing ablative tumor cell death, our nanoimmunotherapy alters the surface levels of co-stimulatory, antigen-presenting, and co-inhibitory molecules on neuroblastoma tumor cells. When administered in a syngeneic, murine model of neuroblastoma bearing synchronous Neuro2a tumors, the CpG-PBNP-PTT plus aCTLA-4 nanoimmunotherapy elicits complete tumor regression in both primary (CpG-PBNP-PTT-treated) and secondary tumors, and long-term survival in a significantly higher proportion (55.5%) of treated-mice compared with the controls. Furthermore, the surviving, nanoimmunotherapy-treated animals reject Neuro2a rechallenge, suggesting that the therapy generates immunological memory. Additionally, the depletion of CD4 + , CD8 + , and NK + populations abrogate the observed therapeutic responses of the nanoimmunotherapy. These findings demonstrate the importance of concurrent PTT-based cytotoxicity and the antitumor immune effects of PTT, CpG, and aCTLA-4 in generating a robust abscopal effect against neuroblastoma.

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Prussian blue nanoparticle-based antigenicity and adjuvanticity trigger robust antitumor immune responses against neuroblastoma

Abstract: Photothermal therapy using CpG oligodeoxynucleotide-coated Prussian blue nanoparticles increases the tumor antigenicity and adjuvanticity, eliciting long-term tumor regression and immunological memory.

Cited by 41 publications

References 50 publications

A Long‐Life Battery‐Type Electrochromic Window with Remarkable Energy Storage Ability

A Long‐Life Battery‐Type Electrochromic Window with Remarkable Energy Storage Ability

Persistent Regulation of Tumor Hypoxia Microenvironment via a Bioinspired Pt‐Based Oxygen Nanogenerator for Multimodal Imaging‐Guided Synergistic Phototherapy

CpG-coated prussian blue nanoparticles-based photothermal therapy combined with anti-CTLA-4 immune checkpoint blockade triggers a robust abscopal effect against neuroblastoma

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