Pruritus and Hyperesthesia Caused by Partial Sensory Denervation

Aubrun, Enrique A.

doi:10.1001/archderm.1936.01470160011002

Cited by 7 publications

(2 citation statements)

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“…When he examined the skin's histology, he identified hair follicle atrophy, while the sweat and sebaceous glands were unaffected . These studies were not universally accepted however, and Aubrun concluded that the alopecia was merely a consequence of scratching . A more intriguing variation on the neuropathic theory was put forward by Jacquet.…”

Section: Alopecia Areata As An Atrophic Nerve Disordermentioning

confidence: 99%

“…[93,94] These studies were not universally accepted however, [95] and Aubrun concluded that the alopecia was merely a consequence of scratching. [96] A more intriguing variation on the neuropathic theory was put forward by Jacquet. He suggested AA was initiated by nerve irritation caused by defective and diseased teeth.…”

Section: Alopecia Are Ata a S An Atrophi C Nerve Disordermentioning

confidence: 99%

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A “hair‐raising” history of alopecia areata

Broadley

McElwee

2020

Experimental Dermatology

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A 3500‐year‐old papyrus from ancient Egypt provides a list of treatments for many diseases including “bite hair loss,” most likely alopecia areata (AA). The treatment of AA remained largely unchanged for over 1500 years. In 30 CE, Celsus described AA presenting as scalp alopecia in spots or the “windings of a snake” and suggested treatment with caustic compounds and scarification. The first “modern” description of AA came in 1813, though treatment still largely employed caustic agents. From the mid‐19th century onwards, various hypotheses of AA development were put forward including infectious microbes (1843), nerve defects (1858), physical trauma and psychological stress (1881), focal inflammation (1891), diseased teeth (1902), toxins (1912) and endocrine disorders (1913). The 1950s brought new treatment developments with the first use of corticosteroid compounds (1952), and the first suggestion that AA was an autoimmune disease (1958). Research progressively shifted towards identifying hair follicle‐specific autoantibodies (1995). The potential role of lymphocytes in AA was made implicit with immunohistological studies (1980s). However, studies confirming their functional role were not published until the development of rodent models (1990s). Genetic studies, particularly genome‐wide association studies, have now come to the forefront and open up a new era of AA investigation (2000s). Today, AA research is actively focused on genetics, the microbiome, dietary modulators, the role of atopy, immune cell types in AA pathogenesis, primary antigenic targets, mechanisms by which immune cells influence hair growth, and of course the development of new treatments based on these discoveries.

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Section: Alopecia Areata As An Atrophic Nerve Disordermentioning

confidence: 99%

Section: Alopecia Are Ata a S An Atrophi C Nerve Disordermentioning

confidence: 99%