1991
DOI: 10.1001/archderm.127.1.125
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Pruritic urticarial plaques and papules of pregnancy and skin distention

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Cited by 12 publications
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“…Stretching and breakage of skin connective tissue can produce an immune reaction by revealing antigens otherwise hidden from the maternal immune system [11]. Pregnancy is known to be associated with peripheral blood microchimerism, particularly during the third trimester, the time when PUPPP classically occurs [12,13].…”
Section: Discussionmentioning
confidence: 99%
“…Stretching and breakage of skin connective tissue can produce an immune reaction by revealing antigens otherwise hidden from the maternal immune system [11]. Pregnancy is known to be associated with peripheral blood microchimerism, particularly during the third trimester, the time when PUPPP classically occurs [12,13].…”
Section: Discussionmentioning
confidence: 99%
“…The exact cause of PUPPP is not well understood and has been theorized to be related to the extensive distension of the abdominal skin late in the gestational period. The rash is more common in women with large weight gains, multiple gestation pregnancy, or polyhydraminos (Beckett & Goldberg, 1991;Cohen, Capeless, Krusinski, & Maloney, 1989). Other suggested causes such as immunologic or hormonal pregnancy-related changes, fetal abnormalities, allergy, or preeclampsia have not been fully investigated or confirmed (Matz, Orion, & Wolf, 2006).…”
Section: Introductionmentioning
confidence: 99%