Pruritic Urticarial Papules and Plaques of Pregnancy

Polymorphic eruption of pregnancy (PEP) is a benign, self-limiting, pruritic disorder of pregnancy, which usually affects the primigravida during the last trimester or immediately postpartum. Its pathogenesis is unclear and its clinical manifestations are variable, leading frequently to an incorrect diagnosis. In cases of PEP the histological findings are nonspecific and the laboratory results, including direct immunofluorescence (DIF) and indirect immunofluorescence (IIF), are negative. Polymorphic eruption of pregnancy is not associated with any fetal risk and symptomatic treatment is all that is usually required. In this review we present the clinical presentation of PEP and a differential diagnosis which defines PEP as a separate entity. We will also review all current data of possible etiologic factors, histologic and immunologic findings, prognosis and therapy.

show abstract

“…Early delivery in refractory cases 30 has not gained support. Only one case of transient neonatal PEP involvement has been described 52 …”

Section: Prognosismentioning

confidence: 99%

Polymorphic eruption of pregnancy

2006

View full text Add to dashboard Cite

show abstract

“…No maternal-fetal mortality has been encountered. There is a case published by Uhlin (5) in which a newborn presented urticariform papules that as toxic erythema (I 7) that is found in diverse der pregnancies went to term, birth was normal, and the newborns were healthy. Two of the women have gone on to give later births without compli • cations or recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…General analytical infor mation on blood and urine was found in all of the cases. Chorionic gonadotropin (CG) levels were determined in 5 cases. Both the papule and urticariform plaque le sions were biopsied in the 14 patients.…”

Section: Methodsmentioning

confidence: 99%

Pruritic urticarial papules and plaques of pregnancy (PUPPP)

Noguera,

Moreno,

Moragas

1983

Acta Derm Venereol

View full text Add to dashboard Cite

show abstract

Pruritic Urticarial Papules and Plaques of Pregnancy and Its Relationship to Maternal-Fetal Weight Gain and Twin Pregnancy

Cohen

Capeless²,

Krusinski³

et al. 1989

Arch Dermatol

141

View full text Add to dashboard Cite

Thirty women who were seen at our institution between 1984 and 1988 for pruritic urticarial papules and plaques of pregnancy (PUPPP) were retrospectively evaluated and interviewed. We found a significantly increased maternal weight gain and newborn birth weight in patients with PUPPP, compared with age and parity-matched controls. The average weight gain during pregnancy was 18.1 +/- 0.9 (SEM) kg for the patients with PUPPP (excluding twin gestations) and 14.6 +/- 1.0 kg for the controls. The mean newborn birth weight was 3.6 +/- 0.09 kg for the PUPPP group and 3.3 +/- 0.08 kg for the control group. There were three twin pregnancies (10%), compared with the twin gestation rate at our institution of 1.6%. Therefore, based on our findings of an increased maternal weight gain and neonatal birth weight, an increased twin rate, and an abdominal eruption that occurs in primigravidas in their third trimester of pregnancy, we suggest that abdominal distention or a reaction to it may play a role in the development of PUPPP.

show abstract

Pruritic Urticarial Papules and Plaques of Pregnancy

Cited by 20 publications

References 4 publications

Polymorphic eruption of pregnancy

Polymorphic eruption of pregnancy

Pruritic urticarial papules and plaques of pregnancy (PUPPP)

Pruritic Urticarial Papules and Plaques of Pregnancy and Its Relationship to Maternal-Fetal Weight Gain and Twin Pregnancy

Contact Info

Product

Resources

About