Pruritic urticarial papules and plaques of pregnancy. Involvement in mother and infant

Uhlin, S. R.

doi:10.1001/archderm.117.4.238

Cited by 9 publications

(4 citation statements)

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“…None of the 193 neonates in this study had any skin lesions. Similar observations were made in all previous studies but one 20 . In the latter report, however, the possibility of pemphigoid gestationis was not ruled out by IF investigations.…”

Section: Discussionsupporting

confidence: 89%

Polymorphic eruption of pregnancy: clinicopathology and potential trigger factors in 181 patients

Rudolph

Al-Fares

Vaughan-Jones

et al. 2005

British Journal of Dermatology

125

181

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Our data confirm the benign, self-limiting nature of PEP and its favourable outcome for both the mother and the fetus. For the first time, we have documented a characteristic change in morphology with disease progression. The evidence of polymorphous clinical features in more than one-half of the patients favours the use of the term PEP. Multiple gestation pregnancies and excessive maternal weight gain, but not fetal weight and sex, were found to be significantly associated with PEP.

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Section: Discussionsupporting

confidence: 89%

Polymorphic eruption of pregnancy: clinicopathology and potential trigger factors in 181 patients

Rudolph

Al-Fares

Vaughan-Jones

et al. 2005

British Journal of Dermatology

125

181

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“…Only one case of transient neonatal PEP involvement has been described. 52 Finally, PEP usually does not recur in subsequent pregnancies; when this happens the condition is much less severe and the eruption is often developed during the first or second trimester and is resolved prepartum. 10 Therefore, the first episode of PEP is the most severe and recurrence occurs in very few cases, in contrast to PG.…”

Section: Prognosismentioning

confidence: 99%

“…Early delivery in refractory cases 30 has not gained support. Only one case of transient neonatal PEP involvement has been described 52 …”

Section: Prognosismentioning

confidence: 99%

Polymorphic eruption of pregnancy

2006

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Polymorphic eruption of pregnancy (PEP) is a benign, self-limiting, pruritic disorder of pregnancy, which usually affects the primigravida during the last trimester or immediately postpartum. Its pathogenesis is unclear and its clinical manifestations are variable, leading frequently to an incorrect diagnosis. In cases of PEP the histological findings are nonspecific and the laboratory results, including direct immunofluorescence (DIF) and indirect immunofluorescence (IIF), are negative. Polymorphic eruption of pregnancy is not associated with any fetal risk and symptomatic treatment is all that is usually required. In this review we present the clinical presentation of PEP and a differential diagnosis which defines PEP as a separate entity. We will also review all current data of possible etiologic factors, histologic and immunologic findings, prognosis and therapy.

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“…The eruption cleared rapidly post-partum and was not associated with an adverse prognosis for either the mother or the newborn, nor was it recurrent in subsequent pregnancies. Reports by other authors [2][3][4][5][6][7][8][9] confirmed PUPPP to be a valid clini-cal entity, but by 1982 only 14 cases had been recorded in the American literature. The histologie features identified were superficial perivascular lymphohistiocytic infiltrate with eosinophils sparsely present in some biopsies.…”

Section: Introductionmentioning

confidence: 99%

Pruritic urticarial papules and plaques of pregnancy (PUPPP): a clinicopathological review of 35 patients

Powell¹,

Dervan²,

Wayte³

et al. 1996

Acad Dermatol Venereol

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The clinical features of 35 cases of Pruritic Urticarial Papules and Plaques of Pregnancy (PUPPP) seen over an 8 year period were reviewed with regard to age and gestational stage of onset, evolution and severity of disease and response to therapy. The histologic features in biopsies from 15 patients were analysed for pattern and extent of inflammatory change and the composition of the inflammatory cells were studied with a panel of monoclonal antibodies. This study confirmed PUPPP to be a well defined clinical entity mainly occurring in young primagravidas in the third trimester and usually responsive to topical treatments. Histologically, perivascular upper and mid-dermal inflammatory changes were present in all biopsies with epidermal spongiosis and vesiculation a prominant feature in many cases. The inflammatory infiltrate was composed of an admixture of T lymphocytes and macrophages.Keywords: Pruritic urticarial papules and plaques of pregnancy (PUPPP); Clinical histologic features; Monoclonal antibodies 0926-9959/96/515.00 © 1996 Elsevier Science B.V. All rights reserved SSDI 0926-9959(95)00108-5

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Pruritic urticarial papules and plaques of pregnancy. Involvement in mother and infant

Cited by 9 publications

References 0 publications

Polymorphic eruption of pregnancy: clinicopathology and potential trigger factors in 181 patients

Polymorphic eruption of pregnancy: clinicopathology and potential trigger factors in 181 patients

Polymorphic eruption of pregnancy

Pruritic urticarial papules and plaques of pregnancy (PUPPP): a clinicopathological review of 35 patients

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