Proximal and distal esophageal contractions have similar manometric features

Peghini, Paolo L.; Pursnani, Kishore; Gideon, Matthew; Castell, June A.; Nierman, Jennifer; Castell, Donald O.

doi:10.1152/ajpgi.1998.274.2.g325

Cited by 19 publications

(21 citation statements)

References 16 publications

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“…We performed the measurement at a site that has more than 50% of striated muscle. The manometric behavior of the striated muscle portion of the proximal esophagus shows characteristics similar to those of distal esophageal smooth muscle and different from the striated muscle of the pharynx (19). The slower contraction of the striated esophageal muscle than the striated muscle of the pharynx makes our perfusion system adequate to measure contraction.…”

Section: Discussionmentioning

confidence: 92%

Esophageal striated muscle contractions in patients with Chagas' disease and idiopathic achalasia

Dantas

Aprile

Aben-Athar

et al. 2002

Braz J Med Biol Res

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Section: Discussionmentioning

confidence: 92%

Esophageal striated muscle contractions in patients with Chagas' disease and idiopathic achalasia

Dantas

Aprile

Aben-Athar

et al. 2002

Braz J Med Biol Res

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“…Evaluating the presence of distinct pressure zones in the esophagus Peghini et al reported a low pressure zone in 26% of patients with esophageal symptoms and 18% of healthy volunteers 16 . The difference between these and our findings (i.e.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of the Esophageal Low-Pressure Zone in Healthy Volunteers and Patients With Esophageal Symptoms: Assessment by High-Resolution Manometry

Pohl

Ribolsi

Savarino

et al. 2008

The American Journal of Gastroenterology

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BACKGROUND: Esophageal motility studies in humans have documented a low-pressure zone (LPZ) in the area of transition from striated to smooth muscle. While preliminary studies indicate that a bolus might be retained in this area, the clinical relevance of the LPZ remains unclear. AIM: To investigate a possible relationship between esophageal symptoms and the size of the esophageal LPZ. METHODS: We reviewed high-resolution manometry (HRM) data from patients with esophageal symptoms (dysphagia, chest pain, and heartburn/regurgitation) and asymptomatic volunteers. The proximal border of the LPZ was defined as the point where the amplitude of the proximal contraction wave declined below 30 mmHg, and the distal border as the point where the distal contraction wave first increased above 30 mmHg. RESULTS: The average (+/-standard error of mean [SEM]) length of the LPZ in 44 asymptomatic individuals was 5.4 +/-0.6 cm and did not differ (P= 0.222) from the LPZ in 64 patients with dysphagia (6.8 +/-0.4 cm), 34 patients with chest pain (6.4 +/-0.6 cm), and 42 patients with gastroesophageal reflux disease (GERD) symptoms (7.0 +/-0.6 cm). These results did not change when the length of the LPZ was corrected for total esophageal length. The time width of the LPZ in asymptomatic individuals (1.6 +/-0.2 s) was shorter than in patients with dysphagia and GERD symptoms (dysphagia 2.4 +/-0.2 s, GERD symptoms 2.8 +/-0.3 s). CONCLUSION: A time delay between the proximal and distal esophageal contraction waves might be a meaningful variable in GERD and dysphagia.Pohl et al. 1

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“…1). Interestingly, the proximal striated muscle of the human esophagus behaves manometrically more like the distal smooth muscle rather than like the striated muscle of the pharynx, i.e., striated muscle of the proximal esophagus contracts more slowly than expected (Peghini et al, 1998). The mechanism of this contraction delay is unclear.…”

Section: Functional Considerationsmentioning

confidence: 97%

Enteric co-innervation of motor endplates in the esophagus: state of the art ten years after

Wörl

Neuhuber

2005

Histochem Cell Biol

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The existence of a distinct ganglionated myenteric plexus between the two layers of the striated tunica muscularis of the mammalian esophagus represented an enigma for quite a while. Although an enteric co-innervation of vagally innervated motor endplates in the esophagus has been repeatedly suggested, it was not possible until recently to demonstrate this dual innervation. Ten years ago, we were able to demonstrate that motor endplates in the rat esophagus receive a dual innervation from both vagal nerve fibers originating in the brain stem and from varicose enteric nerve fibers originating in the myenteric plexus. Since then, a considerable amount of data could be raised on enteric co-innervation and its occurrence in a variety of species, including humans, its neurochemistry, spatial relationships on motor endplates, ontogeny, and possible roles during esophageal peristalsis. These data underline the significance of this newly discovered innervation component, although its function is still largely unknown. The aim of this review is to summarize current knowledge about enteric co-innervation of esophageal striated muscle and to provide some hints as to its functional significance.

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Proximal and distal esophageal contractions have similar manometric features

Cited by 19 publications

References 16 publications

Esophageal striated muscle contractions in patients with Chagas' disease and idiopathic achalasia

Esophageal striated muscle contractions in patients with Chagas' disease and idiopathic achalasia

Characteristics of the Esophageal Low-Pressure Zone in Healthy Volunteers and Patients With Esophageal Symptoms: Assessment by High-Resolution Manometry

Enteric co-innervation of motor endplates in the esophagus: state of the art ten years after

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