Cell Reports volume 4, issue 1, P50-58 2013 DOI: 10.1016/j.celrep.2013.06.003 View full text
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Sharon Schlesinger, Andreia H. Lee, Gary Z. Wang, Lisa Green, Stephen P. Goff

Abstract: Summary Embryonic cells transcriptionally repress the expression of endogenous and exogenous retroelements. Trim28, a key player in this silencing, is known to act in a large DNA-bound complex, but the other components of the complex are not fully characterized. Here we show that the zinc finger protein Yin Yang 1 (YY1) is one such component. YY1 binds to the LTR region of both exogenous and endogenous retroviruses (ERVs). Deletion of the YY1 binding site from the retroviral genome leads to major loss of sile…

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