Proton versus photon therapy for high-risk prostate cancer with dose escalation of dominant intraprostatic lesions: a preliminary planning study
Ashley Li Kuan Ong,
Kellie Knight,
Vanessa Panettieri
et al.
Abstract:Background and purposeThis study aimed to investigate the feasibility of safe-dose escalation to dominant intraprostatic lesions (DILs) and assess the clinical impact using dose-volume (DV) and biological metrics in photon and proton therapy. Biological parameters defined as late grade ≥ 2 gastrointestinal (GI) and genitourinary (GU) derived from planned (DP) and accumulated dose (DA) were utilized.Materials and methodsIn total, 10 patients with high-risk prostate cancer with multiparametric MRI-defined DILs w… Show more
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