Proton Radiotherapy for Pediatric Ewing's Sarcoma: Initial Clinical Outcomes

Rombi, Barbara; DeLaney, Thomas F.; MacDonald, Shannon M.; Huang, Mary; Ebb, David H.; Liebsch, Norbert J.; Raskin, Kevin A.; Yeap, Beow Y.; Marcus, Karen J.; Tarbell, Nancy J.; Yock, Torunn I.

doi:10.1016/j.ijrobp.2011.03.038

Cited by 98 publications

(64 citation statements)

References 41 publications

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“…Studies of tumours outside the cns-including skull base chordoma and chondrosarcoma 22,23 , uveal melanoma 23,24 , germ-cell tumours 25 , high-risk neuroblastoma 26,27 , parameningeal rhabdomyosarcoma 28 , bladder and prostate rhabdomyosarcoma 29 , other soft tissue sarcomas 30 , Ewing sarcoma 31 , and mediastinal Hodgkin lymphoma 32 -uniformly showed that pbt is well tolerated, with local control rates similar to or higher than those achieved with photon rt. Although planning studies and early clinical results are promising, long-term data supporting a clear advantage of pbt over photon rt are not yet available.…”

Section: Pediatricsmentioning

confidence: 99%

Recommendations for the Referral of Patients for Proton-Beam Therapy, an Alberta Health Services Report: A Model for Canada?

et al. 2014

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able and willing to travel abroad to a proton facility. Commonly accepted indications for referral include chordoma and chondrosarcoma, intraocular melanoma, and solid tumours in children and adolescents who have the greatest risk for long-term sequelae. Current data do not provide sufficient evidence to recommend routine referral of patients with most head-and-neck, breast, lung, gastrointestinal tract, and pelvic cancers, including prostate cancer. It is recommended that all referrals be considered by a multidisciplinary team to select appropriate cases.

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Section: Pediatricsmentioning

confidence: 99%

Recommendations for the Referral of Patients for Proton-Beam Therapy, an Alberta Health Services Report: A Model for Canada?

et al. 2014

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“…Particle radiotherapy, the most common being proton radiotherapy, is currently being utilized for treatment of pediatric sarcomas. 110,111 In contrast to photons, protons and other charged particles have a discrete stopping distance that minimizes exposure of normal tissues to unnecessary radiotherapy 112 as well as allowing dose escalation and improved local control in tumors adjacent to critical structures such as the spine and skull base. 113 Second malignancy risk reduction is one of the expected long-term improvements in late effects because the radiation exposure is generally reduced by 60% to 70% in comparison to photon plans.…”

Section: New Directionsmentioning

confidence: 99%

Common Musculoskeletal Tumors of Childhood and Adolescence

Arndt¹,

Rose²,

Folpe³

et al. 2012

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129

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Osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma are the most common malignant musculoskeletal tumors in children and adolescents. Today, most patients can be cured. Numerous factors have contributed to improved outcome for these patients over the past several decades. These include multidisciplinary care involving oncologists, radiation oncologists, surgeons, pathologists, and radiologists and enrollment of patients in clinical trials. Better understanding of molecular mechanisms of disease have resulted in studies using molecular targets in addition to standard chemotherapeutic agents, which hopefully will lead to better outcomes in the future. Moreover, new orthopedic techniques and devices as well as new technologies in radiation oncology hold promise for better local control of primary tumors and the potential for fewer late adverse effects. Despite this progress, patients must undergo lifelong follow-up for possible late effects of intense chemotherapy and radiation therapy. We review the diagnosis, prognosis, staging, multidisciplinary therapy, new directions in therapy, and long-term complications of treatment for these tumors. For this review, we searched MEDLINE using the terms rhabdomyosarcoma, osteosarcoma, Ewing sarcoma, biology, and humans and limited the search to articles from 2000 to September 2011. Additional references found in these articles were utilized as appropriate, as well as references from the background information in current therapeutic studies of the Children's Oncology Group. The same database and time frame were searched for articles written by leading authorities in the field.

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“…All patients who developed spine deformities had laminectomies before proton treatment. Secondary hematological malignancy was an issue with 4 of 30 patients developing an acute myelocytic leukemia or a myelodysplastic syndrome (Rombi et al 2012 ).…”

Section: Vertebral Columnmentioning

confidence: 99%