Proton pump inhibitor therapy may alter the sensory motor characteristics of pharyngoesophageal motility in infants with suspected GERD
Sudarshan R. Jadcherla,
Roseanna Helmick,
Kathryn A. Hasenstab
et al.
Abstract:BackgroundAcid reflux index (ARI) is a biomarker for gastroesophageal reflux disease (GERD). The effects of short‐term proton pump inhibitor (PPI) therapy on pharyngoesophageal motility and clearance mechanisms in infants remain unknown. We hypothesized that pharyngoesophageal reflexes and response to PPI are distinct between infants with 3%–7% and >7% ARI.MethodsSecondary analysis was performed from a subset of infants who participated in a randomized controlled trial (NCT: 02486263). Infants (N = 36, 29.9… Show more
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