JAMA
 2007
DOI: 10.1001/jama.297.13.1429-a
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Proton Pump Inhibitor Therapy and Hip Fracture Risk

Jordan L. Geller1,
John S. Adams2
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Cited by 12 publications

(5 citation statements)
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“…• The infections, particularly, the bacterial pneumopathies [24] and the intestinal infections, especially to Clostridium difficilae [25] • Osteoporotic fractures [26,27] • On the other hand, medicines decreasing the acid gastric secretion such as the long-term PPI would be theoretically capable of leading the genesis of gastric tumors, and even colorectal; in fact, the hypergastrinemia is led by these treatments [28,29].…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…• The infections, particularly, the bacterial pneumopathies [24] and the intestinal infections, especially to Clostridium difficilae [25] • Osteoporotic fractures [26,27] • On the other hand, medicines decreasing the acid gastric secretion such as the long-term PPI would be theoretically capable of leading the genesis of gastric tumors, and even colorectal; in fact, the hypergastrinemia is led by these treatments [28,29].…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…These drugs have been associated with increased fracture risk (9)(10)(11). Based on previous studies, we identified several drugs as potential confounders because of their potential effects on bone metabolism (bone metabolism-related drugs) and their potential to increase the risk of falls (fall-inducing drugs) (19,24,25). Bone metabolism-related drugs (14 categories) included drugs for peptic ulcers and gastroesophageal reflux disease (A02B); steroids (H02A and H02B); thyroid hormones (H03 A); hormones and related agents (L02A); hormone antagonists and related agents (L02B); vitamin D agents (A11C); vitamin B agents (A11D); calcium agents (A12A); anabolic steroids (A14A); vitamin K agents (B02B); statins (C10A); estrogen agonists (G03A, G03C, G03E, G03F, G03G, G03 X, and H01C); anterior pituitary lobe hormones and analogs (H01A); and bisphosphonates and receptor activator of NF-κB ligand (RANKL)-targeted antibody (M05B).…”
Section: Medicationsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Alternative diagnosis and confirmation of laryngeal inflammation should be sought by laryngoscopy. 228 There are also potential risks to prolonged PPI/H2RA use, including associations with impaired cognition (H2RA, 229,230 PPI 231 ), bacterial gastroenteritis (PPI, [232][233][234][235] acid-suppressing medications 236 ), community-acquired pneumonia (PPI 237 ), drug interactions (eg, PPI and clopidogrel 238,239 ), hip fractures (PPI [240][241][242][243][244] ), decreased vitamin B12 levels (PPI 245 ), hypomagnesemia (acid-lowering agents 246 ), and chronic kidney disease (PPI 247 ). Associated risk and increased attention to cost-effective practice has raised questions about the safety and utility of longterm PPI use.…”
Section: Antireflux Medications and The Empiric Treatment Of Dysphoniamentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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