Proton‐minibeam radiation therapy: A proof of concept

Prezado, Yolanda; Fois, Giovanna Rosa

doi:10.1118/1.4791648

Cited by 99 publications

(158 citation statements)

References 61 publications

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“…1 as well as in the Tables 1 and 2 one may conclude that a brass collimators provide better results. The remarkable feature of the simulations is that for both collimator types high PVDR values are observed on the way from the surface to a target (tumor), while nearly homogeneous dose distribution is realized at the depth of the target (tumor) -5 cm, thus illustrating a possibility to realize this important additional advantageous feature of the hadron fractionated therapy [7].…”

Section: Monte Carlo Simulations For the Fractionated Hadron Radiatiomentioning

confidence: 85%

“…The major factor is evolution of PVDR over the depth in phantom. It was pointed out in [7], that one would expect the best results from mini-beam fractionated therapy in case of such shaping of beams that PVDR produced on their way to the tumor are largest in the healthy tissue, while fractionation degrades at the depth of the tumor. The scattering of protons by the slit/holes edges as well as the contamination by the secondary products generated in the collimators makes also fractionation less pronounced.…”

Section: Monte Carlo Simulations For the Fractionated Hadron Radiatiomentioning

confidence: 99%

“…Hadron therapy could benefit further from a lower impact on normal tissues if combined with established tissue-sparing effect of spatially fractionated beams, observed in biological studies performed with synchrotron radiation [4 -6]. The conceptual advantages of Hadron Minibeam Radiation Therapy have been discussed elsewhere [7]. Monte Carlo simulations of dose distribution resulting from spatially fractionated irradiations have stimulated the interest of performing experiments in order to crosscheck these evaluations [8].…”

Section: Introductionmentioning

confidence: 99%

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Shaping and monitoring of the mini-beam structures for the spatially fractionated hadron radiation therapy

Momot¹,

Kovalchuk²,

Okhrimenko

et al. 2016

Nucl. Phys. At. Energy

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Design of collimators and their effectiveness for the purposes of the fractionated mini-beam hadron radiation therapy were evaluated by Monte Carlo simulations. The calculations have been performed for proton, carbon and oxygen ion beams at the energies relevant for medical applications. Micropixel metal and hybrid detectors were tested for measuring charged particles intensity distribution in multi-beam structures shaped by slit or matrix collimators exploring low energy proton beam at the Tandem generator (INR NASU, Kyiv). The results obtained illustrate reliable performance of the designed collimators as well as hybrid and metal microdetectors for measuring and imaging in real time the proton intensity distribution over mini-beam structures.Keywords: spatially fractionated hadron radiation therapy, beam collimators, Monte Carlo simulation of dose distribution, monitoring of spatial distribution of the intensity of the charged particle beams, micropixel metal and hybrid detectors.

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Section: Monte Carlo Simulations For the Fractionated Hadron Radiatiomentioning

confidence: 85%

Section: Monte Carlo Simulations For the Fractionated Hadron Radiatiomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Shaping and monitoring of the mini-beam structures for the spatially fractionated hadron radiation therapy

Momot¹,

Kovalchuk²,

Okhrimenko

et al. 2016

Nucl. Phys. At. Energy

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“…The MRT principle, originally developed for photon microbeams can also be applied using narrowly collimated and closely spaced proton beams [3,4]. Zlobinskaya et al [4] proposed microchannel diameters ranging between 50 mm and 500 mm and suggested the distance between the channels (point-to-point distance, d) to be at least 10 times larger than the microchannel radius.…”

Section: Introductionmentioning

confidence: 99%

Proton microbeam radiotherapy with scanned pencil-beams – Monte Carlo simulations

2015

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Irradiation, delivered by a synchrotron facility, using a set of highly collimated, narrow and parallel photon beams spaced by 1 mm or less, has been termed Microbeam Radiation Therapy (MRT). The tolerance of healthy tissue after MRT was found to be better than after standard broad X-ray beams, together with a more pronounced response of malignant tissue. The microbeam spacing and transverse peak-to-valley dose ratio (PVDR) are considered to be relevant biological MRT parameters. We investigated the MRT concept for proton microbeams, where we expected different depth-dose profiles and PVDR dependences, resulting in skin sparing and homogeneous dose distributions at larger beam depths, due to differences between interactions of proton and photon beams in tissue. Using the FLUKA Monte Carlo code we simulated PVDR distributions for differently spaced 0.1 mm (sigma) pencil-beams of entrance energies 60, 80, 100 and 120 MeV irradiating a cylindrical water phantom with and without a bone layer, representing human head. We calculated PVDR distributions and evaluated uniformity of target irradiation at distal beam ranges of 60-120 MeV microbeams. We also calculated PVDR distributions for a 60 MeV spread-out Bragg peak microbeam configuration. Application of optimised proton MRT in terms of spot size, pencil-beam distribution, entrance beam energy, multiport irradiation, combined with relevant radiobiological investigations, could pave the way for hypofractionation scenarios where tissue sparing at the entrance, better malignant tissue response and better dose conformity of target volume irradiation could be achieved, compared with present proton beam radiotherapy configurations.

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“…Previous models for creating proton microbeams (10 mm diameter) for radiosurgery have shown that surface dose can increase to levels far above the Bragg peak dose as the beam diameter is made smaller (12)(13)(14). The potential benefits of IMPT using DSS need to be weighed against the possibility of unintentional adverse effects, such as overdosing superficial normal tissues at the entrance area of the beam.…”

Section: Introductionmentioning

confidence: 99%

Effect of Scanning Beam for Superficial Dose in Proton Therapy

Moskvin

Estabrook

Cheng

et al. 2014

Technol Cancer Res Treat

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Proton beam delivery technology is under development to minimize the scanning spot size for uniform dose to target, but it is also known that the superficial dose could be as high as the dose at Bragg peak for narrow and small proton beams. The objective of this study is to explore the characteristics of dose distribution at shallow depths using Monte Carlo simulation with the FLUKA code for uniform scanning (US) and discrete spot scanning (DSS) proton beams. The results show that the superficial dose for DSS is relatively high compared to US.Additionally, DSS delivers a highly heterogeneous dose to the irradiated surface for comparable doses at Bragg peak. Our simulation shows that the superficial dose can become as

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Proton‐minibeam radiation therapy: A proof of concept

Cited by 99 publications

References 61 publications

Shaping and monitoring of the mini-beam structures for the spatially fractionated hadron radiation therapy

Shaping and monitoring of the mini-beam structures for the spatially fractionated hadron radiation therapy

Proton microbeam radiotherapy with scanned pencil-beams – Monte Carlo simulations

Effect of Scanning Beam for Superficial Dose in Proton Therapy

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