Proton Magnetic Resonance Spectroscopy of Vascular- and Alzheimer-Type Dementia

Abstract

Proton magnetic resonance spectroscopy may be useful in distinguishing between dementia of the Alzheimer type and vascular dementia.

In Vivo Brain Concentrations of N-Acetyl Compounds, Creatine, and Choline in Alzheimer Disease

“…Consistent with other in vivo 31,[44][45][46][47][70][71][72] and ex vivo or postmortem 33,54,73,74 reports, NAc concentration, whether expressed as a ratio of Cr or Cho or in absolute terms, was substantially lower in patients with AD than in age-matched controls. Kwo-On-Yeun et al 54 also noted substantially more reduction in NAc in gray matter than in white matter in comparing patients with AD to controls.…”

In Vivo Brain Concentrations of N-Acetyl Compounds, Creatine, and Choline in Alzheimer Disease

“…Consistent with other in vivo 31,[44][45][46][47][70][71][72] and ex vivo or postmortem 33,54,73,74 reports, NAc concentration, whether expressed as a ratio of Cr or Cho or in absolute terms, was substantially lower in patients with AD than in age-matched controls. Kwo-On-Yeun et al 54 also noted substantially more reduction in NAc in gray matter than in white matter in comparing patients with AD to controls.…”

Multimodality Imaging Approaches in Alzheimer's disease. Part II: 1H MR spectroscopy, FDG PET and Amyloid PET

“…Study by Waldman 23 found higher mI/Cr ratio in AD patients than vascular dementia patients. In contrast with results of Kattapong, 22 they reported similar findings of NAA/Cr or NAA/Cho between clinical groups. They mentioned that it may reflect the small sample of control subjects and possibly the method of measuring peak heights from spectra, which are scaled to the amplitude of NAA.…”

Hydrogen Proton Magnetic Resonance Spectroscopy in Multidomain Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment Without Dementia

“…20 –25 Zhu et al 26 found that there were differences in NAA–Cr related to brain regions between different types of MCI. Kattapong et al 27 also reported that the NAA–Cr and NAA–Cho ratios in the subcortical white matter of patients with VD were significantly reduced compared with patients with AD. In this study, we detected similar changes in NAA levels between patients with M-aMCI and VCIND.…”

In Vivo Brain Concentrations of N-Acetyl Compounds, Creatine, and Choline in Alzheimer Disease

“…Consistent with other in vivo 31,[44][45][46][47][70][71][72] and ex vivo or postmortem 33,54,73,74 reports, NAc concentration, whether expressed as a ratio of Cr or Cho or in absolute terms, was substantially lower in patients with AD than in age-matched controls. Kwo-On-Yeun et al 54 also noted substantially more reduction in NAc in gray matter than in white matter in comparing patients with AD to controls.…”

Multimodality Imaging Approaches in Alzheimer's disease. Part II: 1H MR spectroscopy, FDG PET and Amyloid PET

“…Study by Waldman 23 found higher mI/Cr ratio in AD patients than vascular dementia patients. In contrast with results of Kattapong, 22 they reported similar findings of NAA/Cr or NAA/Cho between clinical groups. They mentioned that it may reflect the small sample of control subjects and possibly the method of measuring peak heights from spectra, which are scaled to the amplitude of NAA.…”

Hydrogen Proton Magnetic Resonance Spectroscopy in Multidomain Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment Without Dementia

“…20 –25 Zhu et al 26 found that there were differences in NAA–Cr related to brain regions between different types of MCI. Kattapong et al 27 also reported that the NAA–Cr and NAA–Cho ratios in the subcortical white matter of patients with VD were significantly reduced compared with patients with AD. In this study, we detected similar changes in NAA levels between patients with M-aMCI and VCIND.…”

In Vivo Brain Concentrations of N-Acetyl Compounds, Creatine, and Choline in Alzheimer Disease

“…Consistent with other in vivo 31,[44][45][46][47][70][71][72] and ex vivo or postmortem 33,54,73,74 reports, NAc concentration, whether expressed as a ratio of Cr or Cho or in absolute terms, was substantially lower in patients with AD than in age-matched controls. Kwo-On-Yeun et al 54 also noted substantially more reduction in NAc in gray matter than in white matter in comparing patients with AD to controls.…”

Multimodality Imaging Approaches in Alzheimer's disease. Part II: 1H MR spectroscopy, FDG PET and Amyloid PET

“…Study by Waldman 23 found higher mI/Cr ratio in AD patients than vascular dementia patients. In contrast with results of Kattapong, 22 they reported similar findings of NAA/Cr or NAA/Cho between clinical groups. They mentioned that it may reflect the small sample of control subjects and possibly the method of measuring peak heights from spectra, which are scaled to the amplitude of NAA.…”

Hydrogen Proton Magnetic Resonance Spectroscopy in Multidomain Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment Without Dementia

“…20 –25 Zhu et al 26 found that there were differences in NAA–Cr related to brain regions between different types of MCI. Kattapong et al 27 also reported that the NAA–Cr and NAA–Cho ratios in the subcortical white matter of patients with VD were significantly reduced compared with patients with AD. In this study, we detected similar changes in NAA levels between patients with M-aMCI and VCIND.…”