Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland

Preliminary results of proton radiotherapy for choroidal melanoma – the Kraków experience

“…In the case of brachytherapy applicators are used (in the form of plaques) with a radioactive isotope (iodine-125, ruthenium-106, palladium-103) [ 13 , 14 ]. This method has been practised since the 1930s and its 5-year survival rate of around 80% is comparable with the results observed for enucleation [ 15 , 16 ]. Thanks to these factors and the possibility of preserving the eyeball, brachytherapy has become the standard procedure for patients with choroidal melanoma.…”

“…noted the following complications following proton radiotherapy: retinopathy (39%), cataracts (20%), inflammation of the uvea (17%), neuropathy (16%) and maculopathy (4%). Despite this fact, when the results in terms of local control are considered, the authors believe that proton radiotherapy is an effective method for treating patients with choroidal melanoma [ 15 ].…”

Preliminary results of proton radiotherapy for choroidal melanoma – the Kraków experience

“…In the case of brachytherapy applicators are used (in the form of plaques) with a radioactive isotope (iodine-125, ruthenium-106, palladium-103) [ 13 , 14 ]. This method has been practised since the 1930s and its 5-year survival rate of around 80% is comparable with the results observed for enucleation [ 15 , 16 ]. Thanks to these factors and the possibility of preserving the eyeball, brachytherapy has become the standard procedure for patients with choroidal melanoma.…”

“…noted the following complications following proton radiotherapy: retinopathy (39%), cataracts (20%), inflammation of the uvea (17%), neuropathy (16%) and maculopathy (4%). Despite this fact, when the results in terms of local control are considered, the authors believe that proton radiotherapy is an effective method for treating patients with choroidal melanoma [ 15 ].…”

Uveal Melanoma: Molecular Pattern, Clinical Features, and Radiation Response

“…After proton beam radiation therapy, rate of tumor shrinkage may not correlate with pretreatment tumor size. 22,24 While some analyses have shown that after helium ion or proton beam irradiation there was a strong relationship between the rate of tumor regression and metastatic risk, 25,26 our multivariate results indicated that only molecular class was a significant predictor of development of metastasis and DSS. Similarly, postradiation tumor recurrence was not predicted by molecular tumor class.…”

Carbon Ion Versus Photon-based Stereotactic Ablative Radiation Therapy for Patients with Choroidal Melanoma

“… 23 Although no direct comparative studies between CIRT and PBT have been conducted specifically for choroidal melanoma, the review of existing literature suggests that CIRT offers similar or slightly superior tumor control rates, with PBT showing a 5-year local failure-free rates of 87% to 96%. 24 , 25 , 26 Such findings underscore the need for further direct comparisons between the different RT modalities to fully evaluate the relative effectiveness of CIRT.…”

Preliminary results of proton radiotherapy for choroidal melanoma – the Kraków experience

“…In the case of brachytherapy applicators are used (in the form of plaques) with a radioactive isotope (iodine-125, ruthenium-106, palladium-103) [ 13 , 14 ]. This method has been practised since the 1930s and its 5-year survival rate of around 80% is comparable with the results observed for enucleation [ 15 , 16 ]. Thanks to these factors and the possibility of preserving the eyeball, brachytherapy has become the standard procedure for patients with choroidal melanoma.…”

“…noted the following complications following proton radiotherapy: retinopathy (39%), cataracts (20%), inflammation of the uvea (17%), neuropathy (16%) and maculopathy (4%). Despite this fact, when the results in terms of local control are considered, the authors believe that proton radiotherapy is an effective method for treating patients with choroidal melanoma [ 15 ].…”

Uveal Melanoma: Molecular Pattern, Clinical Features, and Radiation Response

“…After proton beam radiation therapy, rate of tumor shrinkage may not correlate with pretreatment tumor size. 22,24 While some analyses have shown that after helium ion or proton beam irradiation there was a strong relationship between the rate of tumor regression and metastatic risk, 25,26 our multivariate results indicated that only molecular class was a significant predictor of development of metastasis and DSS. Similarly, postradiation tumor recurrence was not predicted by molecular tumor class.…”

Carbon Ion Versus Photon-based Stereotactic Ablative Radiation Therapy for Patients with Choroidal Melanoma

“… 23 Although no direct comparative studies between CIRT and PBT have been conducted specifically for choroidal melanoma, the review of existing literature suggests that CIRT offers similar or slightly superior tumor control rates, with PBT showing a 5-year local failure-free rates of 87% to 96%. 24 , 25 , 26 Such findings underscore the need for further direct comparisons between the different RT modalities to fully evaluate the relative effectiveness of CIRT.…”

Preliminary results of proton radiotherapy for choroidal melanoma – the Kraków experience

“…In the case of brachytherapy applicators are used (in the form of plaques) with a radioactive isotope (iodine-125, ruthenium-106, palladium-103) [ 13 , 14 ]. This method has been practised since the 1930s and its 5-year survival rate of around 80% is comparable with the results observed for enucleation [ 15 , 16 ]. Thanks to these factors and the possibility of preserving the eyeball, brachytherapy has become the standard procedure for patients with choroidal melanoma.…”

“…noted the following complications following proton radiotherapy: retinopathy (39%), cataracts (20%), inflammation of the uvea (17%), neuropathy (16%) and maculopathy (4%). Despite this fact, when the results in terms of local control are considered, the authors believe that proton radiotherapy is an effective method for treating patients with choroidal melanoma [ 15 ].…”

Uveal Melanoma: Molecular Pattern, Clinical Features, and Radiation Response

“…After proton beam radiation therapy, rate of tumor shrinkage may not correlate with pretreatment tumor size. 22,24 While some analyses have shown that after helium ion or proton beam irradiation there was a strong relationship between the rate of tumor regression and metastatic risk, 25,26 our multivariate results indicated that only molecular class was a significant predictor of development of metastasis and DSS. Similarly, postradiation tumor recurrence was not predicted by molecular tumor class.…”

Carbon Ion Versus Photon-based Stereotactic Ablative Radiation Therapy for Patients with Choroidal Melanoma

“… 23 Although no direct comparative studies between CIRT and PBT have been conducted specifically for choroidal melanoma, the review of existing literature suggests that CIRT offers similar or slightly superior tumor control rates, with PBT showing a 5-year local failure-free rates of 87% to 96%. 24 , 25 , 26 Such findings underscore the need for further direct comparisons between the different RT modalities to fully evaluate the relative effectiveness of CIRT.…”