Proton beam radiotherapy for uveal melanoma: Results of Curie Institut–Orsay Proton Therapy Center (ICPO)

Recommendations for the Referral of Patients for Proton-Beam Therapy, an Alberta Health Services Report: A Model for Canada?

“…Protons are useful in treating larger tumours or tumours close to the fovea or optic disc that are not suitable for plaque brachytherapy. Local control and eye preservation rates exceed 90% at 5 years [42][43][44][45][46] . In 59 patients treated with pbt at triumf in Vancouver, the 5-year actuarial local control rate was 91% (97% in patients treated with 60 GyE), with an overall eye conservation rate of 80% 46 .…”

Radiotherapy for ocular tumours

“…The position of the eye is fixed according to the location of the tumour by fixing the contralateral eye on a specified point. Doses of 60 Gy in four fractions 38,39 and 70 Gy in five fractions 40 have been used. This latter dose has been reduced to 50 Gy also in five fractions, but without any significant difference in either local control or complications.…”

“…This latter dose has been reduced to 50 Gy also in five fractions, but without any significant difference in either local control or complications. 39 Local control with protons is about 95% in most series. [38][39][40] Stereotactic RT with a g knife started with 55 Gy in one fraction, reducing slowly over several years of experience to 31 Gy.…”

“…39 Local control with protons is about 95% in most series. [38][39][40] Stereotactic RT with a g knife started with 55 Gy in one fraction, reducing slowly over several years of experience to 31 Gy. With a stereotactic linear accelerator, 60-70 Gy in five fractions was given but this was then reduced to 50 Gy.…”

ECCO essential requirements for quality cancer care for melanoma: Defining how to organise care

“…Radiotherapy also has an important role in the treatment of melanoma brain metastases, by stereotactic or whole brain radiation. For uveal melanoma, radiotherapy (proton therapy and ocular brachytherapy) is the best conservative treatment giving excellent local control rates (Dendale et al, 2006;American Brachytherapy Society, 2014). For conjunctival and mucosal melanomas, adjuvant irradiation is part of the therapeutic strategy that increases local control rates.…”