volume 1, issue 2, P100094 2020
DOI: 10.1016/j.xpro.2020.100094
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Abstract: SUMMARY Destabilizing domains (DDs) have been used successfully to conditionally control the abundance of proteins of interest (POIs) in a small-molecule-dependent manner in mice, worms ( Caenorhabditis elegans ), and Drosophila . However, development of such systems must account for delivery of the DD-POIs to the target tissue, accessibility of the target tissue to the small molecule, and quantification of stabilization. Here, we describe the considerat…

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