Prothrombotic risk factors in ischemic stroke and migraine in children

Pilarska, Ewa; Lemka, Małgorzata; Bakowska, Alicja

doi:10.1111/j.1600-0404.2006.00599.x

Cited by 22 publications

(12 citation statements)

References 34 publications

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“…Increased plasma levels of its soluble forms may indicate loss of TM from the EC membrane and thus a procoagulant state [152], and the decrease of soluble TM levels may be considered favourable with respect to cardiovascular risk [153]. In 30 children after ischemic stroke were found increased levels of aCL, anti-β2GPI, and TM compared with healthy controls [154]. Experimental data showed that four of eighteen aCL antibodies, derived from NZB/WF1 mouse reacted with rabbit TM and induced down-regulation of TM on endothelial cells, followed by induction of thrombosis [155].…”

Section: Monocytesmentioning

confidence: 93%

Some Recent Insights into the Prothrombogenic Mechanisms of Antiphospholipid Antibodies

Todorova¹,

Baleva

2007

CMC

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Antiphospholipid antibodies (aPL) are a heterogeneous group of autoantibodies, detected in the sera of patients with both autoimmune and various non-autoimmune diseases. They are also detected in subjects with no overt underlying disease - the primary antiphosphilipid syndrome (PAPS). High titers of APL are associated with arterial and venous thrombosis, recurrent fetal loss and thrombocytopenia. There have been many suggestions explaining the potential mechanisms of the procoagulant effect of aPL. These include endothelial cell (EC) activation; increased adhesion molecule expression; inhibition of EC prostacyclin release, increased leucocyte adhesion to EC, downregulation of thrombomodulin expression. APL induce the procoagulant activity of monocytes via increased tissue factor expression and directly stimulate platelet hyperactivity with resultant production of enhanced amounts of the proaggregatory molecule of TXA(2). In vitro studies show that prepro-endothelin-1 mRNA is induced by human monoclonal anticardiolipin antibodies and this might contribute to vasospasm, and, ultimately, to arterial occlusion. The hypercoagulable state in APS patients is associated with alterations in the protein C/S pathway. It is suggested that aPL may impair the protein C anticoagulant system. Acquired protein C and protein S deficiency is described in patients with APS. Beta2- glycoprotein I, (Beta2-GPI) a natural anticoagulant, is involved in the regulation of protein S anticoagulant activity by preventing the binding of protein S to C4b-binding protein. APL were shown to inhibit this effect of Beta2- GP I. As the group of aPL is very heterogeneous, it is unlikely that a single mechanism is responsible for the thrombogenic activity of all aPLs associated with thrombosis.

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Section: Monocytesmentioning

confidence: 93%

Some Recent Insights into the Prothrombogenic Mechanisms of Antiphospholipid Antibodies

Todorova¹,

Baleva

2007

CMC

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“…The role aPL play in migraine has been studied before, and there is evidence both for and against aPL involvement in children (9)(10)(11)(12) and adults (13)(14)(15)(16). Many of the studies reported to date were small and poorly controlled.…”

Section: Introductionmentioning

confidence: 99%

Migraine and Antiphospholipid Antibodies: No Association Found in Migraine-Discordant Monozygotic Twins

et al. 2008

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Migraine headache (with and without aura) is common in the general population and is known to be influenced by genetic factors with heritability estimates between 34-57%. Antiphospholipid syndrome (APS) is a hypercoagulable state characterized by clinical features including venous and arterial thromboses, pregnancy loss and migraine, and by association with antiphospholipid antibodies (aPL). Numerous small studies have investigated whether aPL are associated with migraine in the general population--with contradictory results. In this study, the question was addressed by studying the prevalence of aPL in members of monozygotic (MZ) twin pairs differing in their migraine status. Such twins provide a unique natural experiment, matched as they are for age, sex and genetic factors, and allow the role of environmental factors, such as aPL, to be determined. Despite 95% power to detect a difference of 0.59 IgG units per litre in anticardiolipin antibody IgG titres, no difference in prevalence of aPL could be detected in migraine-discordant MZ twins.

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“…In turn, repetitive SDs in pathological states are noxious to the brain, and may affect disease progression of certain vasculopathies. Further supporting the concept of microvascular occlusion triggering migraine attacks in susceptible brains, several reports describe an association of migraine with hypercoagulable and prothrombotic states, or persistent foramen ovale …”

Section: The Association Of Migraine and Chronic Vasculopathiesmentioning

confidence: 84%

“…Further supporting the concept of microvascular occlusion triggering migraine attacks in susceptible brains, several reports describe an association of migraine with hypercoagulable and prothrombotic states, or persistent foramen ovale. 5,[22][23][24][25][26][27] In summary, we applaud Dr. Sacco for discussing broader implications of the observed association between migraine and vascular diseases such as retinal vasculopathies and MI. We emphasize that clinical and experimental evidence at this time is stronger to support SD as a link between migraine and chronic vasculopathies.…”

Section: The Association Of Migraine and Mi/retinal Vasculopathymentioning

confidence: 91%

Migraine, Chronic Vasculopathies, and Spreading Depolarization

Bornstädt

Eikermann-Haerter

2016

Headache

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Prothrombotic risk factors in ischemic stroke and migraine in children

Abstract: The possible role of prothrombotic factors in individual cases of pediatric stroke and migraine cannot be excluded.

Cited by 22 publications

References 34 publications

Some Recent Insights into the Prothrombogenic Mechanisms of Antiphospholipid Antibodies

Some Recent Insights into the Prothrombogenic Mechanisms of Antiphospholipid Antibodies

Migraine and Antiphospholipid Antibodies: No Association Found in Migraine-Discordant Monozygotic Twins

Migraine, Chronic Vasculopathies, and Spreading Depolarization

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