2017
DOI: 10.1038/nrcardio.2017.89
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Abstract: The worldwide increase in life expectancy gives rise to an increasing prevalence of cardiac diseases, which remain the leading cause of disability and death in the developed world [1][2][3] . Currently, the mechanisms under lying how ageing contributes to the initiation or acceler ation of cardiac diseases are essentially unresolved. Prevailing theories of ageing centre on gradual derail ment of cellular protein homeostasis -proteostasis -either by design (genetically) or by 'wear and tear' (environmentally) 3… Show more

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Cited by 130 publications
(112 citation statements)
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“…Although there is only a trend towards an increase in HSPA5 expression in patients with AF, diminished protein synthesis or enhanced degradation, by either the proteasome or autophagy, or exhaustion of the protein levels may be the underlying cause . There is ongoing debate about whether autophagy plays a beneficial or detrimental role in cardiac diseases . Excessive autophagy contributed to age‐related cardiac disease development, including heart failure, hypertension‐induced cardiac diseases, mitral regurgitation, and diabetic cardiomyopathy .…”
Section: Discussionmentioning
confidence: 99%
“…Although there is only a trend towards an increase in HSPA5 expression in patients with AF, diminished protein synthesis or enhanced degradation, by either the proteasome or autophagy, or exhaustion of the protein levels may be the underlying cause . There is ongoing debate about whether autophagy plays a beneficial or detrimental role in cardiac diseases . Excessive autophagy contributed to age‐related cardiac disease development, including heart failure, hypertension‐induced cardiac diseases, mitral regurgitation, and diabetic cardiomyopathy .…”
Section: Discussionmentioning
confidence: 99%
“…Adequate protein turnover is essential for cardiac homeostasis [13]. Different protein quality control mechanisms are involved in the maintenance of protein homeostasis, including molecular chaperones and the autophagy pathway [14].…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, it has been shown that alterations in the proteostasis of cardiomyocytes may play an important role in the development of cardiovascular diseases. 3 Accordingly, several studies have provided evidence for an important role of misfolded proteins in the pathophysiology of heart failure, cardiac hypertrophy, dilated and ischaemic cardiomyopathies, and atrial fibrillation. [4][5][6][7][8][9] Prevailing theories of impaired protein homeostasis mainly focus on disturbances of the fine-tuned balance of cellular production, folding, and degradation of proteins.…”
mentioning
confidence: 99%
“…Cellular accumulation of protein aggregates has been observed in cardiomyocytes from patients with idiopathic dilated or hypertrophic cardiomyopathy, heart failure, and ischaemic heart disease. 3 Since aggregated proteins may become toxic, damage the cell structure and impair cellular functions, it is very likely that protein aggregates play an important pathophysiological role. In addition, local ATP concentrations may be required to stabilize protein domains containing hydrophobic surfaces, thereby ensuring proper protein-protein interactions.…”
mentioning
confidence: 99%
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