2020
DOI: 10.1002/tox.22921
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: The zebrafish (Danio rerio) is a small teleost fish that is becoming increasingly popular in laboratories worldwide and several attributes have also placed the zebrafish under the spotlight of (eco)toxicological studies. Since the 1990s, international organizations such as ISO and OECD have published guidelines for the use of zebrafish in ecotoxicological assessment of environmental toxicants such as the Fish Embryo Acute Toxicity (FET) test, OECD n 236 guideline. This protocol uses 3,4-dichloroaniline (DCA), … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
7
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 16 publications
(7 citation statements)
references
References 45 publications
0
7
0
Order By: Relevance
“…Poor yolk absorption in combination with small larvae following embryonic exposure to crude oil has also been shown in Atlantic haddock ( Melanogrammus aeglefinus ), where mechanistic links to altered cholesterol synthesis and homeostasis was established using transcriptomics [ 56 ]. Proteomics analyses on zebrafish embryos exposed to 3,4-DCA revealed alterations in lipid-related pathways which are involved in mobilization of lipids from yolk sac during early larvae development, with two apolipoproteins (Apo1a and Apo1b) down-regulated by 3,4-DCA-exposure [ 22 ]. Utilization of the yolk sac through transport of lipids are pivotal processes for growth during the yolk-sac period, and disruption of such processes is a possible cause of the 3,4-DCA-treated cod larvae being smaller.…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…Poor yolk absorption in combination with small larvae following embryonic exposure to crude oil has also been shown in Atlantic haddock ( Melanogrammus aeglefinus ), where mechanistic links to altered cholesterol synthesis and homeostasis was established using transcriptomics [ 56 ]. Proteomics analyses on zebrafish embryos exposed to 3,4-DCA revealed alterations in lipid-related pathways which are involved in mobilization of lipids from yolk sac during early larvae development, with two apolipoproteins (Apo1a and Apo1b) down-regulated by 3,4-DCA-exposure [ 22 ]. Utilization of the yolk sac through transport of lipids are pivotal processes for growth during the yolk-sac period, and disruption of such processes is a possible cause of the 3,4-DCA-treated cod larvae being smaller.…”
Section: Resultsmentioning
confidence: 99%
“…3,4-DCA has been detected in various fresh-, brackish- and marine aquatic environments at concentrations up to 0.7 μg/L [ [15] , [16] , [17] , [18] , [19] , [20] ]. As part of the NORMAN list ( http://www.norman-network.net/ ), it is widely recognized as an emerging aquatic pollutant and has a well-documented toxicity towards many standard test species, including several freshwater fish during their early life stages (ELS) [ 21 , 22 ]. 3,4-DCA is thus used as positive control substance in the Fish Embryo Acute Toxicity (FET) test, with a target LC 50 concentration of 4000 μg/L as test validity criterium [ 23 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Anilines prevent the metabolic pathway of unspecific membrane in the cell [1,6]. Embryotoxicity was observed in Javanese medaka [7] and zebrafish (Danio rerio) exposed to sublethal concentration of 3,4-DCA [8] embryos exposed to 3,4-DCA. Moreover, 3,4-DCA has prolonged toxicity in different organisms [9,10].…”
Section: Introductionmentioning
confidence: 99%
“…At 100 and 200-400 µg/L, 3,4-DCA affected the secondary sex characters (male colour intensity and courtship behaviour) and androgen of Gasterosteus aculeatus 96-h post-exposure [1]. It was reported that 3,4-DCA is an endocrine-disrupting compound (EDCs) [3,7,8,16].…”
Section: Introductionmentioning
confidence: 99%