Proteomic profiles in cerebrospinal fluid predicted death and disability in term infants with perinatal asphyxia: A pilot study

Leifsdottir, Kristin; Thelin, Eric Peter; Lassarén, Philipp; Siljehav, Veronica; Nilsson, Peter; Eksborg, Staffan; Herlenius, Eric

doi:10.1111/apa.16277

Cited by 4 publications

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References 42 publications

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“…We have recently revealed how the proteomic profile after perinatal asphyxia can predict death and long-term disability in term infants. In that report we revealed several novel protein biomarkers, that were elevated in term infants with adverse outcome ( 48 ). In contrast to term infants, here lower CSF levels of several mediators of neurodevelopment predicted outcome of preterm infants.…”

Section: Discussionmentioning

confidence: 89%

The cerebrospinal fluid proteome of preterm infants predicts neurodevelopmental outcome

et al. 2022

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BackgroundSurvival rate increases for preterm infants, but long-term neurodevelopmental outcome predictors are lacking. Our primary aim was to determine whether a specific proteomic profile in cerebrospinal fluid (CSF) of preterm infants differs from that of term infants and to identify novel biomarkers of neurodevelopmental outcome in preterm infants.MethodsTwenty-seven preterm infants with median gestational age 27 w + 4 d and ten full-term infants were enrolled prospectively. Protein profiling of CSF were performed utilizing an antibody suspension bead array. The relative levels of 178 unique brain derived proteins and inflammatory mediators, selected from the Human Protein Atlas, were measured.ResultsThe CSF protein profile of preterm infants differed from that of term infants. Increased levels of brain specific proteins that are associated with neurodevelopment and neuroinflammatory pathways made up a distinct protein profile in the preterm infants. The most significant differences were seen in proteins involved in neurodevelopmental regulation and synaptic plasticity, as well as components of the innate immune system. Several proteins correlated with favorable outcome in preterm infants at 18–24 months corrected age. Among the proteins that provided strong predictors of outcome were vascular endothelial growth factor C, Neurocan core protein and seizure protein 6, all highly important in normal brain development.ConclusionOur data suggest a vulnerability of the preterm brain to postnatal events and that alterations in protein levels may contribute to unfavorable neurodevelopmental outcome.

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Section: Discussionmentioning

confidence: 89%

The cerebrospinal fluid proteome of preterm infants predicts neurodevelopmental outcome

et al. 2022

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8-oxoguanine DNA glycosylase-1 may serve as biomarker of mechanical asphyxia

Zhang,

Niu,

Zhou

et al. 2024

Forensic Science International

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Proteomic profiles in cerebrospinal fluid predicted death and disability in term infants with perinatal asphyxia: A pilot study

et al. 2022

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Aim Perinatal asphyxia, resulting in hypoxic‐ischaemic encephalopathy (HIE), has been associated with high mortality rates and severe lifelong neurodevelopmental disabilities. Our aim was to study the association between the proteomic profile in cerebrospinal fluid (CSF) and the degree of HIE and long‐term outcomes. Methods We prospectively enrolled 18‐term born infants with HIE and 10‐term born controls between 2000 and 2004 from the Karolinska University Hospital. An antibody suspension bead array and FlexMap3D analysis was used to characterise 178 unique brain‐derived and inflammation associated proteins in their CSF. Results Increased CSF concentrations of several brain‐specific proteins were observed in the proteome of HIE patients compared with the controls. An upregulation of neuroinflammatory pathways was also noted and this was confirmed by pathway analysis. Principal component analysis revealed a gradient from favourable to unfavourable HIE grades and outcomes. The proteins that provided strong predictors were structural proteins, including myelin basic protein and alpha‐II spectrin. The functional proteins included energy‐related proteins like neuron‐specific enolase and synaptic regulatory proteins. Increased CSF levels of 51 proteins correlated with adverse outcomes in infants with HIE. Conclusion Brain‐specific proteins and neuroinflammatory mediators in CSF may predict HIE degrees and outcomes after perinatal asphyxia.

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Proteomic profiles in cerebrospinal fluid predicted death and disability in term infants with perinatal asphyxia: A pilot study

Cited by 4 publications

References 42 publications

The cerebrospinal fluid proteome of preterm infants predicts neurodevelopmental outcome

The cerebrospinal fluid proteome of preterm infants predicts neurodevelopmental outcome

8-oxoguanine DNA glycosylase-1 may serve as biomarker of mechanical asphyxia

Proteomic profiles in cerebrospinal fluid predicted death and disability in term infants with perinatal asphyxia: A pilot study

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