volume 7, issue 10, P816-838 2015
DOI: 10.18632/aging.100808
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Maria Peiris-Pagès, Duncan L. Smith, Balázs Győrffy, Federica Sotgia, Michael P. Lisanti

Abstract: Cancer cells grow in highly complex stromal microenvironments, which through metabolic remodelling, catabolism, autophagy and inflammation nurture them and are able to facilitate metastasis and resistance to therapy. However, these changes in the metabolic profile of stromal cancer-associated fibroblasts and their impact on cancer initiation, progression and metastasis are not well-known. This is the first study to provide a comprehensive proteomic portrait of the azathioprine and taxol-induced catabolic state…

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