Proteomic Identification of Plasma Components in Tachypleus tridentatus and Their Effects on the Longitudinal Bone Growth Rate in Rats

Jiang, Shengyang; Qu, Xiaoni; Liu, Siping; Wei, Jun-Jie; Yi, Xiangxi; Liu, Yonghong; Gao, Chenghai

doi:10.3390/md21020111

Cited by 2 publications

(2 citation statements)

References 28 publications

(33 reference statements)

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“…Additionally, at a dosage of 200 mg/kg, T. tridentatus plasma increased serum levels of ALP, BMP-2, and IGF-1 in rats. Additionally, it significantly upregulated mRNA expression levels of IGF-1 and IGFBP-3 [74].…”

Section: Tachypleus Tridentatusmentioning

confidence: 97%

The Effects of Natural Product-Derived Extracts for Longitudinal Bone Growth: An Overview of In Vivo Experiments

Lim,

Lee

2023

IJMS

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Approximately 80% of children with short stature are classified as having Idiopathic Short Stature (ISS). While growth hormone (GH) treatment received FDA approval in the United States in 2003, its long-term impact on final height remains debated. Other treatments, like aromatase inhibitors, metformin, and insulin-like growth factor-1 (IGF-1), have been explored, but there is no established standard treatment for ISS. In South Korea and other Asian countries, East Asian Traditional Medicine (EATM) is sometimes employed by parents to potentially enhance their children’s height growth, often involving herbal medicines. One such product, Astragalus membranaceus extract mixture HT042, claims to promote height growth in children and has gained approval from the Korean Food and Drug Administration (KFDA). Research suggests that HT042 supplementation can increase height growth in children without skeletal maturation, possibly by elevating serum IGF-1 and IGF-binding protein-3 levels. Preclinical studies also indicate the potential benefits of natural products, including of EATM therapies for ISS. The purpose of this review is to offer an overview of bone growth factors related to ISS and to investigate the potential of natural products, including herbal preparations, as alternative treatments for managing ISS symptoms, based on their known efficacy in in vivo studies.

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Section: Tachypleus Tridentatusmentioning

confidence: 97%

The Effects of Natural Product-Derived Extracts for Longitudinal Bone Growth: An Overview of In Vivo Experiments

Lim,

Lee

2023

IJMS

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“…With the improvement of economy and living standards, the attention paid to short stature in children has been increasingly highlighted. Short stature in children refers to a height that is 2 standard deviations (SD) below the average for a child's same race, gender, and age in a comparable environment[ 1 ], or a height that falls below the 3rd percentile of the normal population[ 2 ]. Numerous causes can lead to short stature in children, among which growth hormone deficiency (GHD) is a significant factor.…”

Section: Introductionmentioning

confidence: 99%

Effects of different doses of long-acting growth hormone in treating children with growth hormone deficiency

Xia,

Wang,

Pan

2023

World J Clin Cases

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β cells are the main cells responsible for the hypoglycemic function of pancreatic islets, and the insulin secreted by these cells is the only hormone that lowers blood glucose levels in the human body. β cells are regulated by various factors, among which neurotransmitters make an important contribution. This paper discusses the effects of neurotransmitters secreted by various sympathetic and parasympathetic nerves on β cells and summarizes the mechanisms by which various neurotransmitters regulate insulin secretion. Many neurotransmitters do not have a single source and are not only released from nerve terminals but also synthesized by β cells themselves, allowing them to synergistically regulate insulin secretion. Almost all of these neurotransmitters depend on the presence of glucose to function, and their actions are mostly related to the Ca2+ and cAMP concentrations. Although neurotransmitters have been extensively studied, many of their mechanisms remain unclear and require further exploration by researchers.

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Proteomic Identification of Plasma Components in Tachypleus tridentatus and Their Effects on the Longitudinal Bone Growth Rate in Rats

Cited by 2 publications

References 28 publications

The Effects of Natural Product-Derived Extracts for Longitudinal Bone Growth: An Overview of In Vivo Experiments

The Effects of Natural Product-Derived Extracts for Longitudinal Bone Growth: An Overview of In Vivo Experiments

Effects of different doses of long-acting growth hormone in treating children with growth hormone deficiency

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