volume 6, issue 10, P856-872 2014
DOI: 10.18632/aging.100698
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Daniel M. Waldera-Lupa, Faiza Kalfalah, Ana-Maria Florea, Steffen Sass, Fabian Kruse, Vera Rieder, Julia Tigges, Ellen Fritsche, Jean Krutmann, Hauke Busch, Melanie Boerries, Helmut E. Meyer, Fritz Boege, Fabian Theis et al.

Abstract: We analyzed an ex vivo model of in situ aged human dermal fibroblasts, obtained from 15 adult healthy donors from three different age groups using an unbiased quantitative proteome-wide approach applying label-free mass spectrometry. Thereby, we identified 2409 proteins, including 43 proteins with an age-associated abundance change. Most of the differentially abundant proteins have not been described in the context of fibroblasts’ aging before, but the deduced biological processes confirmed known hallmarks of …

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