Abstract:Breast cancer (BrCA) therapeutic selection routinely incorporates clinicopathologic information along with immunohistochemistry (IHC) for ER/PR/HER2/Ki-67. However, this is incomplete and has shortcomings that are seen in clinical outcome differences even within the same subtype. Herein, we analyzed the proteome of 116 HER2-negative primary BrCA samples and subsequently validated a 34-proteogenomic signature in 5,963 BrCA tumor samples from TCGA, METABRIC, and GSE96058 that demonstrated a metabolic enrichment … Show more
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