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Cited by 1,195 publications
(1,039 citation statements)
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References 6 publications
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“…For example, the identification of over 500 bacterial proteins helped researchers find covalent switches on cysteines (7), and over 1,000 proteins were identified from human cells (3). Such advances have driven the detection of whole protein forms, now simply called proteoforms (8), with several laboratories now seeking to tie these to specific functions in cell and disease biology (9 -11).…”
mentioning
confidence: 99%
“…For example, the identification of over 500 bacterial proteins helped researchers find covalent switches on cysteines (7), and over 1,000 proteins were identified from human cells (3). Such advances have driven the detection of whole protein forms, now simply called proteoforms (8), with several laboratories now seeking to tie these to specific functions in cell and disease biology (9 -11).…”
mentioning
confidence: 99%
“…This led to the realization that the complexity and variability of biological machinery exceeds that provided by the genetic code. Such complexity and variation may be explained in large part by the heterogeneity of protein structures [4].…”
Section: Heterogeneity Of Proteinsmentioning
confidence: 99%
“…A result is the production of chemically different forms of the same protein, originally stemming from the same gene, with variation in structure and often, biological activity. Such species have been defined as "proteoforms" [4].…”
Section: Heterogeneity Of Proteinsmentioning
confidence: 99%
“…12 This approach has the advantage that all modifications on the same molecule can be measured together, enabling identification of the precise proteoform. 13 Although this approach seems to be attractive, top-down mass spectrometry is experimentally and computationally challenging because it is difficult to analyze proteins in comparison with peptides and each protein may have multiple proteoforms that might or might not have same function. 8 However, at bottom-up proteomics, proteins are turned into peptides by the enzymatic digestion.…”
Section: -11mentioning
confidence: 99%