Proteins as Active Compounds Involved in Insecticidal Activity of Mushroom Fruitbodies

Wang, Ming; Triguéros, Véronique; Paquereau, Laurent; Chavant, Louis; Fournier, Didier

doi:10.1603/0022-0493-95.3.603

Cited by 48 publications

(30 citation statements)

References 14 publications

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“…Since the fruiting bodies produce and disperse the sexual spores, defense of these structures against fungivores, including predators, grazers, and parasites, is essential for fungal reproduction. Thus, dikaryotic fungi employ, in addition to a large repertoire of secondary metabolites, a plethora of proteins acting as deterrents or toxins in defense of their fruiting bodies (Spiteller 2015;Wang et al 2002). These proteins include lectins that bind to the glycans of glycoproteins or glycolipids in the digestive tract of fungivores , protease inhibitors that inhibit digestive proteases of fungivores (Renko et al 2010), biotinbinding proteins that sequester this essential cofactor (BleulerMartinez et al 2012), pore-forming proteins that cause cell lysis (Mancheno et al 2010;Ota et al 2014), RNA toxins (ribotoxins) that cleave or depurinate RNA molecules (Lacadena et al 2007), and other enzymes including proteases, oxidases, and phospholipases (Erjavec et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Entomotoxic and nematotoxic lectins and protease inhibitors from fungal fruiting bodies

Sabotič

Ohm

Künzler

2015

Appl Microbiol Biotechnol

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Fruiting bodies or sporocarps of dikaryotic (ascomycetous and basidiomycetous) fungi, commonly referred to as mushrooms, are often rich in entomotoxic and nematotoxic proteins that include lectins and protease inhibitors. These protein toxins are thought to act as effectors of an innate defense system of mushrooms against animal predators including fungivorous insects and nematodes. In this review, we summarize current knowledge about the structures, target molecules, and regulation of the biosynthesis of the best characterized representatives of these fungal defense proteins, including galectins, beta-trefoil-type lectins, actinoporin-type lectins, beta-propeller-type lectins and beta-trefoil-type chimerolectins, as well as mycospin and mycocypin families of protease inhibitors. We also present an overview of the phylogenetic distribution of these proteins among a selection of fungal genomes and draw some conclusions about their evolution and physiological function. Finally, we present an outlook for future research directions in this field and their potential applications in medicine and crop protection.

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Section: Introductionmentioning

confidence: 99%

Entomotoxic and nematotoxic lectins and protease inhibitors from fungal fruiting bodies

Sabotič

Ohm

Künzler

2015

Appl Microbiol Biotechnol

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“…Recently, important progress is made in the study of the fungal lectins against pathogens, especially pest insects (karimi et al, 2007 and2008;Francis et al, 2011). Many lectins have been derived from different fungi and partially isolated and characterized for their effects on mammalian physiology as antitumor and anticancer, but there is little information on their role on phytophagous insects (Wang et al, 2002;Trigueros et al, 2003, Karimi et al, 2008. Vasconcelos et al, 2004) Some lectins from fungi including Xerocomus chrysenteron (XCL), Arthrobotrys oligospora (AOL) and Agaricus bisprous (ABL) have been isolated and all are well known for their reversible antiproliferative effects.…”

Section: Fungal Lectins With Insecticidal Activitymentioning

confidence: 99%

Lectins and Their Roles in Pests Control

Karimi¹,

Allahyari²,

Bandani³

2012

New Perspectives in Plant Protection

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“…The tests included determining their rate of hydrocarbon consumption, evaluating the effect of micro-molecules (which can traverse the dialysis membrane, in contrast to macro-molecules and enzymes (Wang et al 2002)), and whether lytic proteases of FBCA origin inhibit the pathogens.…”

Section: Inhibition Of Citrus Green Mould Of Oranges By the Beneficiamentioning

confidence: 99%

The effect of three basidiomycetous fungal species on soil-borne, foliage and fruit-damaging phytopathogens in laboratory experiments

et al. 2011

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The effect of three basidiomycetous fungi, Meira geulakonigii, M. argovae and Acaromyces ingoldii on strains of seven phytopathogenic fungal species was assayed in the laboratory. The phytopathogens were placed on dialysis membranes covering media in which the basidiomycetous fungi were formerly cultured. A. ingoldii inhibited the growth of all phytopathogens tested, whereas Meira spp. suppressed their growth to a lesser extent. Upon being returned to extract-free media, all phytopathogens resumed their growth, suggesting a fungistatic effect of the basidiomycetous fungi. These fungi inhibited the growth of Sclerotina sclerotiorum on tomato leaves for a few days and Meira spp. hindered the infection of oranges by Penicillium digitatum, whereas A. ingoldii was less effective. Results of preliminary biochemical assays suggest that neither competition for hydrocarbons nor secreted proteases are responsible for the inhibitory activity of the basidiomycetous fungi, which was probably due to the secretion of unidentified substances by these fungi.

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Proteins as Active Compounds Involved in Insecticidal Activity of Mushroom Fruitbodies

Cited by 48 publications

References 14 publications

Entomotoxic and nematotoxic lectins and protease inhibitors from fungal fruiting bodies

Entomotoxic and nematotoxic lectins and protease inhibitors from fungal fruiting bodies

Lectins and Their Roles in Pests Control

The effect of three basidiomycetous fungal species on soil-borne, foliage and fruit-damaging phytopathogens in laboratory experiments

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