Protein‐Structure‐Directed Metal–Organic Zeolite‐like Networks as Biomacromolecule Carriers

Abstract

Fabrication of zeolite‐like metal–organic frameworks (ZMOFs) for advanced applications, such as enzyme immobilization, is of great interest but is a great synthetic challenge. Herein, we have developed a new strategy using proteins as structure‐directed agents to direct the formation of new ZMOFs that can act as versatile platforms for the in situ encapsulation of proteins under ambient conditions. Notably, protein incorporation directs the formation of a ZMOF with a sodalite (sod) topology instead of a non‐porous diamondoid (dia) topology under analogous synthetic conditions. Histidines in proteins play a crucial role in the observed templating effect. Modulating histidine content thereby influenced the resultant MOF product (from dia to dia + sod mixture and, ultimately, to sod MOF). Moreover, the resulting ZMOF‐incorporated proteins preserved their activity even after exposure to high temperatures and organic solvents, demonstrating their potential for biocatalysis and biopharmaceutical applications.

Synthesis of a Reactive Template-Induced Core–Shell PZS@ZIF-67 Composite Microspheres and Its Application in Epoxy Composites

“…Novel hybrid nanomaterials with particular surface chemistry and multidimensional geometric nanoarchitecture may promote advanced materials’ rapid evolution. As an important branch of MOFs (metal–organic frameworks), zeolite-like metal–organic frameworks (ZIFs) integrate the advantages of zeolite and MOFs, such as high porosity, cage-like cavities, adjustable pores, designate functions, excellent stability, etc., which caused great application prospects in the fields of efficient catalysis [ 27 , 28 ], energy storage [ 29 , 30 ], gas adsorption separation [ 31 , 32 ], sensor detection [ 33 , 34 ], and immobilized enzymes [ 35 , 36 ]. In recent years, researchers have been focusing on regulating MOFs’ morphology and structure, especially making MOFs exist as ultra-thin flakes, which can effectively increase the coordinatively unsaturated metal sites and further improve their application performance.…”

Catalytic Activity, Stability, and Loading Trends of Alcohol Dehydrogenase Enzyme Encapsulated in a Metal–Organic Framework

“…These interactions are more obvious in PSE, which has received less attention. This being most likely due to the popularity that comes from the ease of synthesis and the loading speed in DNE, with MOFs like zeolitic imidazole framework-8 (or ZIF-8) when compared to the more rigorous organic synthesis required for MOFs suitable for PSE . MOFs used in PSE often have the advantage of having larger pores but suffer from a more difficult, longer synthesis with the infiltration rates and loading of materials not readily available. ,, …”

Laminar flow-assisted synthesis of amorphous ZIF-8-based nano-motor with enhanced transmigration for photothermal cancer therapy

“…S7 †). 25,26 In Fig. 3, the pre-synthesized Pdop NP in the batch exhibited a uniform size of 200 nm with a relatively smooth surface.…”