Protein-stabilized gold nanoclusters for PDT: ROS and singlet oxygen generation

Poderys, Vilius; Jarockytė, Greta; Bagdonas, Saulius; Karabanovas, Vitalijus; Rotomskis, Ričardas

doi:10.1016/j.jphotobiol.2020.111802

Cited by 44 publications

(43 citation statements)

References 34 publications

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“…However, bigger Au NCs with peroxo-like orientation of O 2 is likely to facilitate its dissociation to yield O radicals that initiate the oxidation of the Au-S bonds between protein scaffolds and the encapsulated Au NCs to form bigger Au nanoparticles that may lead to fluorescence quenching. There has been great interest in novel design of complex metal-based nanoarchitectures in the last few years [103,104]. Several approaches have been developed to generate advanced hybrid-based structures with synergistic properties.…”

Section: Photocatalytic Activity Of Noble-metal Clusters For Pdtmentioning

confidence: 99%

Engineered Nanostructured Photocatalysts for Cancer Therapy

2022

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The present review aims at highlighting recent advances in the development of photocatalysts devoted to cancer therapy applications. We pay especial attention to the engineering aspects of different nanomaterials including inorganic semiconductors, organic-based nanostructures, noble metal-based systems or synergistic hybrid heterostructures. Furthermore, we also explore and correlate structural and optical properties with their photocatalytic capability to successfully performing in cancer-related therapies. We have made an especial emphasis to introduce current alternatives to organic photosensitizers (PSs) in photodynamic therapy (PDT), where the effective generation of reactive oxidative species (ROS) is pivotal to boost the efficacy of the treatment. We also overview current efforts in other photocatalytic strategies to tackle cancer based on photothermal treatment, starvation therapy, oxidative stress unbalance via glutathione (GSH) depletion, biorthogonal catalysis or local relief of hypoxic conditions in tumor microenvironments (TME).

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Section: Photocatalytic Activity Of Noble-metal Clusters For Pdtmentioning

confidence: 99%

Engineered Nanostructured Photocatalysts for Cancer Therapy

2022

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“…AuNCs emerge as a promising ideal PS candidate for PDT. For the reasons that AuNCs are chemically pure and have eco-friendly synthesis (Poderys et al, 2020), they exhibit excellent biocompatibility and low toxicity, long tumor retention and rapid normal tissue clearance, and the microsecond (µs) range fluorescence lifetime is conducive to the generation of excess ROS. Dihydrolipoic acidcoated gold nanocluster (AuNC@DHLA) possessed superior two-photon optical properties and strong ROS generation when stimulated by an external laser, and showed highly efficient antitumor effects in a hepatocellular carcinoma xenograft model with negligible toxicity (Han et al, 2020).…”

Section: Photodynamic Therapymentioning

confidence: 99%

Gold Nanoparticles in Cancer Theranostics

Gao

Zhang

Gao

et al. 2021

Front. Bioeng. Biotechnol.

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Conventional cancer treatments, such as surgical resection, radiotherapy, and chemotherapy, have achieved significant progress in cancer therapy. Nevertheless, some limitations (such as toxic side effects) are still existing for conventional therapies, which motivate efforts toward developing novel theranostic avenues. Owning many merits such as easy surface modification, unique optical properties, and high biocompatibility, gold nanoparticles (AuNPs and GNPs) have been engineered to serve as targeted delivery vehicles, molecular probes, sensors, and so on. Their small size and surface characteristics enable them to extravasate and access the tumor microenvironment (TME), which is a promising solution to realize highly effective treatments. Moreover, stimuli-responsive properties (respond to hypoxia and acidic pH) of nanoparticles to TME enable GNPs’ unrivaled control for effective transport of therapeutic cargos. In this review article, we primarily introduce the basic properties of GNPs, further discuss the recent progress in gold nanoparticles for cancer theranostics, with an additional concern about TME stimuli-responsive studies.

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“…This is because of the higher cytotoxicity of the protein conjugated Au-CdSe systems against cancer cells relative to normal cells [70]. In presence of protein, there is elevation of reactive oxygen species (ROS) levels in cancer cells in the hybrid NPprotein-QDs [71][72][73]. At low levels, ROS may play an important role in molecular signaling, regulating fundamental biological processes such as cell viability, proliferation, migration, and differentiation.…”

Section: Molecular Vibrations In Aumentioning

confidence: 99%

Novel gold nanoparticle-protein-semiconductor quantum dot hybrid system: synthesis, characterization and application in cancer cell imaging

Sarma¹,

Das²,

Saikia³

et al. 2021

Nanosystems: Phys. Chem. Math.

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Formation of a hybrid system by metallic nanoparticle, protein (or peptide), and a semiconductor QD can be a new and alternate material which may be used for biological applications including cancer cell detection and treatment. Herein, we report on the colloidal synthesis of metal-protein-QD hybrid system considering Au NPs, CdSe QDs, BSA and Lysozyme protein. We demonstrate the structural, optical and vibrational properties of Au-CdSe, Au-BSA-CdSe and Au-Lysozyme-CdSe hybrid systems following their use as cancer cell markers. The study of photoluminescence spectra reveals the predominance fluorescence resonance energy transfer (FRET) between CdSe QDs and Au NPs, Au-BSA and Au-Lysozyme complex. The energy transfer efficiency between QDs donor and the Au NPs, Au-BSA, Au-Lysozyme acceptors are estimated to be 46%, 94% and 64%; respectively. Fluorescence imaging results represent high biocompatibility and fluorescent behavior of the QDs and its hybrid system in the MDA-MB-231 breast cancer cells. The calculation of corrected total counts of fluorescence (CTCF) predicts the higher uptake of CdSe QDs as compared to the Au-QDs, Au-BSA-QDs, Au-Lysozyme-QDs by the cells. The significantly varied zeta potential values of the hybrid systems influence the cellular uptake processes. The fabrication of biocompatible (water soluble, biologically stable, having bioconjugation capability, low cytotoxic to the normal cells, fluorescent in biological environment) Au-CdSe, Au-protein-CdSe hybrid systems would open up an alternative strategy in nanobiotechnology, due to their special physical, optical as well as chemical properties.

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Protein-stabilized gold nanoclusters for PDT: ROS and singlet oxygen generation

Cited by 44 publications

References 34 publications

Engineered Nanostructured Photocatalysts for Cancer Therapy

Engineered Nanostructured Photocatalysts for Cancer Therapy

Gold Nanoparticles in Cancer Theranostics

Novel gold nanoparticle-protein-semiconductor quantum dot hybrid system: synthesis, characterization and application in cancer cell imaging

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