Protein Quality Control and Lipid Droplet Metabolism

Roberts, Melissa A.; Olzmann, James A.

doi:10.1146/annurev-cellbio-031320-101827

Cited by 70 publications

(72 citation statements)

References 192 publications

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“…They serve as a store for cholesterol esters and triacylglycerols (TAGs) utilized for membrane formation and maintenance but also supply essential lipids to produce signalling molecules and metabolic energy. LDs also have a more dynamic role since proteins present in the lipid droplet coat regulate lipid homeostasis, and therefore, LDs play a very important role in the regulation of intracellular lipid storage and lipid metabolism [ 65 ]. Single-strand RNA viruses, including coronaviruses, target LDs during their replication phase [ 66 , 67 ].…”

Section: Lipid Metabolic Remodelling Of the Host Cellmentioning

confidence: 99%

Dissecting lipid metabolism alterations in SARS-CoV-2

Casari

Manfredi

Metharom

et al. 2021

Progress in Lipid Research

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic that has infected over sixteen million people globally. There have been more than two million deaths recorded worldwide, with no end in sight until a vaccine is developed. Current research has centred on different aspects of the virus interaction with cell surface receptors, but more needs to be done to further understand its mechanism of action in order to develop a targeted therapy and a method to control the spread of the virus. Lipids play a crucial role throughout the viral life cycle, and viruses are known to exploit lipid signalling and synthesis to affect host cell lipidome. Emerging studies using untargeted metabolomic and lipidomic approaches are providing new insight into the host response to COVID-19 infection. Indeed, metabolomic and lipidomic approaches have identified numerous circulating lipids that directly correlate to the severity of the disease, making lipid metabolism a potential therapeutic target. Circulating lipids play a key function in the pathogenesis of the virus and exert an inflammatory response. A better knowledge of lipid metabolism in the host-pathogen interaction will provide valuable insights into viral pathogenesis and to develop novel therapeutic targets.

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Section: Lipid Metabolic Remodelling Of the Host Cellmentioning

confidence: 99%

Dissecting lipid metabolism alterations in SARS-CoV-2

Casari

Manfredi

Metharom

et al. 2021

Progress in Lipid Research

View full text Add to dashboard Cite

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“…In addition to its role in autophagic protein degradation, p62 has been proposed to participate in a Parkin-independent mitophagy mechanism that counteracts liver damage during NAFLD (Yamada et al, 2018). Regarding its role in lipid metabolism, it is not clear whether p62 acts directly as an adaptor that targets LDs to autophagic degradation, although there is data indicating it is present on the surface of the LDs and required for lipophagy (reviewed by Roberts and Olzmann, 2020). Finally, p62 is an important connector of autophagy and other cellular protective pathways.…”

Section: Autophagy Markersmentioning

confidence: 99%

Autophagy in Hepatic Steatosis: A Structured Review

Ramos

Kowaltowski

Kakimoto

2021

Front. Cell Dev. Biol.

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Steatosis is the accumulation of neutral lipids in the cytoplasm. In the liver, it is associated with overeating and a sedentary lifestyle, but may also be a result of xenobiotic toxicity and genetics. Non-alcoholic fatty liver disease (NAFLD) defines an array of liver conditions varying from simple steatosis to inflammation and fibrosis. Over the last years, autophagic processes have been shown to be directly associated with the development and progression of these conditions. However, the precise role of autophagy in steatosis development is still unclear. Specifically, autophagy is necessary for the regulation of basic metabolism in hepatocytes, such as glycogenolysis and gluconeogenesis, response to insulin and glucagon signaling, and cellular responses to free amino acid contents. Also, genetic knockout models for autophagy-related proteins suggest a critical relationship between autophagy and hepatic lipid metabolism, but some results are still ambiguous. While autophagy may seem necessary to support lipid oxidation in some contexts, other evidence suggests that autophagic activity can lead to lipid accumulation instead. This structured literature review aims to critically discuss, compare, and organize results over the last 10 years regarding rodent steatosis models that measured several autophagy markers, with genetic and pharmacological interventions that may help elucidate the molecular mechanisms involved.

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“…Starting with the discovery by Antony van Leeuwenhoek in 1674, LD biology has taken a sweeping 300 year-long developmental path to the modern era. Our understanding has accelerated in the last two decades, importantly marked by the discovery of marker proteins, development of methods for purification, and the application of omics studies (Ding et al, 2013;Roberts and Olzmann, 2020).…”

Section: Introductionmentioning

confidence: 99%

Two Types of Contact Between Lipid Droplets and Mitochondria

Cui

Liu

2020

Front. Cell Dev. Biol.

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Lipid droplets (LDs) and mitochondria are essential organelles involved in cellular lipid metabolism and energy homeostasis. Accumulated studies have revealed that the physical contact between these two organelles is important for their functions. Current understanding of the contact between cellular organelles is highly dynamic, fitting a “kiss-and-run” model. The same pattern of contact between LDs and mitochondria has been reported and several proteins are found to mediate this contact, such as perilipin1 (PLIN1) and PLIN5. Another format of the contact has also been found and termed anchoring. LD-anchored mitochondria (LDAM) are identified in oxidative tissues including brown adipose tissue (BAT), skeletal muscle, and heart muscle, and this anchoring between these two organelles is conserved from mouse to monkey. Moreover, this anchoring is generated during the brown/beige adipocyte differentiation. In this review, we will summarize previous studies on the interaction between LDs and mitochondria, categorize the types of the contacts into dynamic and stable/anchored, present their similarities and differences, discuss their potential distinct molecular mechanism, and finally propose a working hypothesis that may explain why and how cells use two patterns of contact between LDs and mitochondria.

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Protein Quality Control and Lipid Droplet Metabolism

Cited by 70 publications

References 192 publications

Dissecting lipid metabolism alterations in SARS-CoV-2

Dissecting lipid metabolism alterations in SARS-CoV-2

Autophagy in Hepatic Steatosis: A Structured Review

Two Types of Contact Between Lipid Droplets and Mitochondria

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