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Cited by 140 publications
(88 citation statements)
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References 81 publications
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“…Upon phosphorylation, FAK contributes to MAPK activation via interaction with c-src, Grb2, and the small GTPase Ras (Schlaepfer et al, 1997(Schlaepfer et al, , 1998(Schlaepfer et al, , 1999. This is significant since MAPK activation is also one of the effectors of oscillatory flow in bone cells (You et al, 2001) and this pathway has been observed in response to fluid flow in endothelial cells (Berk et al, 1995;Ishida et al, 1996;Li et al, 1997). It is also notable that FAK activation has been observed to cause intracellular calcium mobilization via activation of the γ1 isoform of PLC (the only SH2 containing isoform known).…”
Section: Integrins and Integrin Associated Proteinsmentioning
confidence: 99%
“…Upon phosphorylation, FAK contributes to MAPK activation via interaction with c-src, Grb2, and the small GTPase Ras (Schlaepfer et al, 1997(Schlaepfer et al, , 1998(Schlaepfer et al, , 1999. This is significant since MAPK activation is also one of the effectors of oscillatory flow in bone cells (You et al, 2001) and this pathway has been observed in response to fluid flow in endothelial cells (Berk et al, 1995;Ishida et al, 1996;Li et al, 1997). It is also notable that FAK activation has been observed to cause intracellular calcium mobilization via activation of the γ1 isoform of PLC (the only SH2 containing isoform known).…”
Section: Integrins and Integrin Associated Proteinsmentioning
confidence: 99%
“…PKA mediates several of the effects of the elevated levels of cAMP in the cells and has been reported to both activate and inhibit the ERK1/2 signaling pathway either directly or through the activation of Rap1 (45). Although both PKA and PKC can modulate the activity of ERK1/2 pathways by phosphorylation of Raf kinases, PKA preferentially targets B-Raf, whereas PKC alters the activity of the Raf-1 isoform (7,45,54,57).…”
Section: Fig 10mentioning
confidence: 99%
“…It is well recognized that when ECs are subjected to hemodynamic forces, Ca 2ϩ mobilization plays an essential role in endothelial responses (20,35). When ECs are under hemodynamic treatment, a rapid increase of [Ca 2ϩ ] i (35,36), inositol triphosphate and DAG (17) occurs. DAG is produced from hydrolysis of PI and PC (17).…”
Section: Sequential Activation Of Pkc-␣ and -⑀ Contributes To Strainimentioning
confidence: 99%