2019
DOI: 10.3389/fcell.2019.00039
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Abstract: Acute or chronic injury to the central nervous system (CNS), causes neuronal death and irreversible cognitive deficits or sensory-motor alteration. Despite the capacity of the adult CNS to generate new neurons from neural stem cells (NSC), neuronal replacement following an injury is a restricted process, which does not naturally result in functional regeneration. Therefore, potentiating endogenous neurogenesis is one of the strategies that are currently being under study to regenerate damaged brain tissue. The… Show more

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Cited by 26 publications
(28 citation statements)
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“…The lathyrane EOF2 (CAS number 2230806-06-9) was previously described by our group as a diterpene with no effect on NPC proliferation 22 . Since other diterpenes induced proliferation of NPC 24 via classical PKC activation 23 , we analyzed its capacity to activate PKC and to facilitate the generation of neurospheres. Although EOF2 treatment increased PKC activity by twofold in neurosphere cultures (supplementary fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The lathyrane EOF2 (CAS number 2230806-06-9) was previously described by our group as a diterpene with no effect on NPC proliferation 22 . Since other diterpenes induced proliferation of NPC 24 via classical PKC activation 23 , we analyzed its capacity to activate PKC and to facilitate the generation of neurospheres. Although EOF2 treatment increased PKC activity by twofold in neurosphere cultures (supplementary fig.…”
Section: Resultsmentioning
confidence: 99%
“…Neuregulin-mediated activation of ErbB4 favors neurogenesis in the adult brain promoting neuroblast survival and organizing migration of neuroblasts from the SVZ towards the olfactory bulb 20,21 . Considering these findings, it seems reasonable to hypothesize that specific activation of different PKC isozymes would alter the pattern of growth factor secretion within neurogenic niches, and will regulate either proliferation-mediated by classical PKCβ and α 22 -or neuroblast survival and migration-mediated by novel PKC isozymes 23 . Consequently, in order to promote neurogenesis in injuries, it would be useful to find molecules with the capacity to activate novel PKC specifically facilitating neuregulins release.…”
Section: Introductionmentioning
confidence: 99%
“…Tyrosine-protein kinases are activated (NMDA and VGCC mechanisms) and modulated by Ca 2+ ions and other enzymes such as Calmodulin, us-ing multiplicative intracellular mechanisms and further potentiation of the postsynaptic channels. Other protein kinases (PKA and PKC) also have an influential role in the synaptic efficiency, phosphorylating, and modulating pre-and postsynaptic ionic channels (Geribaldi-Doldán et al, 2019).…”
Section: Protein-kinasesmentioning
confidence: 99%
“…Together, these results suggest that GTP-induced differentiation is strictly dependent on a cooperative mechanism in the signal transduction between NGF and GTP after the purine binding on specific sites [39]. Similarly, guanosine also induced neurite outgrowth in cerebellar neurons, under hypoxic conditions [40]. Guanosine and GMP were also able to promote the reorganization of extracellular matrix proteins in astrocytes and increase the number of neurons in a neuron-astrocyte co-culture system through the involvement of A2A adenosine receptors and extracellular signaling pathways formed by several kinases as extracellular-regulated kinases, calcium-calmodulin-dependent kinase, protein kinase C and protein kinase A [41].…”
Section: Specific Effects Of Gbps In Nervous Tissuementioning
confidence: 69%