Protein hydration, stability and unfolding

Knaggs, MH; Williams, Mark A.; Goodfellow, Julia M.

doi:10.1042/bst0230711

Cited by 2 publications

(1 citation statement)

References 9 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other words, this theory of life predicts that RNA, nucleotides, organic bases have prominent and direct roles in protein metabolism. This protease-independent model of protein structure remodeling is consistent with data suggesting that changing levels of water (oxygyre), hormones and fatty acids (carbogyre), phosphorylation (phosphogyre), and amino acids (ribogyre) directly impact protein stability [ 509 , 510 , 511 , 512 , 513 ]. This model also provides a unique perspective on polypeptide evolution: ribon (nucleotides, RNA, amine)-based cycling through and into the aminonexus ( aminocycle ) allows the generation and feedback of domains and enzymatic activities into subgyres.…”

Section: Theorysupporting

confidence: 85%

Theory of the Origin, Evolution, and Nature of Life

Andrulis

2011

Life

View full text Add to dashboard Cite

Life is an inordinately complex unsolved puzzle. Despite significant theoretical progress, experimental anomalies, paradoxes, and enigmas have revealed paradigmatic limitations. Thus, the advancement of scientific understanding requires new models that resolve fundamental problems. Here, I present a theoretical framework that economically fits evidence accumulated from examinations of life. This theory is based upon a straightforward and non-mathematical core model and proposes unique yet empirically consistent explanations for major phenomena including, but not limited to, quantum gravity, phase transitions of water, why living systems are predominantly CHNOPS (carbon, hydrogen, nitrogen, oxygen, phosphorus, and sulfur), homochirality of sugars and amino acids, homeoviscous adaptation, triplet code, and DNA mutations. The theoretical framework unifies the macrocosmic and microcosmic realms, validates predicted laws of nature, and solves the puzzle of the origin and evolution of cellular life in the universe.

show abstract