2021
DOI: 10.1186/s12917-021-03080-9
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Abstract: Background Tear film (TF) helps maintain and protect ocular function against damage to the ocular surface. Proteins are one of its main constituents, whose expression pattern can be used as a biomarker of ocular changes and systemic diseases. The aim of this study was to evaluate the expression of proteins in the TF of domestic cats before and after infection with Toxoplasma gondii, in the phases of acute infection and chronicity. Twelve healthy cats received orally homogenized brain matter obt… Show more

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Cited by 1 publication
(2 citation statements)
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References 75 publications
(101 reference statements)
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“…Mass spectrometry has been used for protein analysis, cytokine measurements, and drug concentration studies in tears from different species. Tears from cats with Toxoplasma gondii were evaluated by proteomic analysis and mass spectrometry enabling the identification of 54 proteins, 37 of which were consistent with healthy felines 8 . Doxycycline levels in equine tears were evaluated using liquid chromatography with tandem mass spectrometric detection, resulting in the ability to track drug concentrations in the tear film for up to 10 days 9 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Mass spectrometry has been used for protein analysis, cytokine measurements, and drug concentration studies in tears from different species. Tears from cats with Toxoplasma gondii were evaluated by proteomic analysis and mass spectrometry enabling the identification of 54 proteins, 37 of which were consistent with healthy felines 8 . Doxycycline levels in equine tears were evaluated using liquid chromatography with tandem mass spectrometric detection, resulting in the ability to track drug concentrations in the tear film for up to 10 days 9 .…”
Section: Discussionmentioning
confidence: 99%
“…Tears from cats with Toxoplasma gondii were evaluated by proteomic analysis and mass spectrometry enabling the identification of 54 proteins, 37 of which were consistent with healthy felines. 8 Doxycycline levels in equine tears were evaluated using liquid chromatography with tandem mass spectrometric detection, resulting in the ability to track drug concentrations in the tear film for up to 10 days. 9 Finally, mass spectrometry has been used to evaluate canine tears for the concentration of Cannabidiol (CBD) following oral administration of this drug.…”
Section: Discussionmentioning
confidence: 99%