Saccharomyces cerevisiae biomass is one of the microbes of food safety. In animals, Saccharomyces cerevisiae in their diets are known to play several vital roles including prevention of diarrhea and mortality, boosting of immune system, performance, milk production, fiber degradation and nutrient digestability, adsorption of toxic metal such as cadmium, stabilization of rumen pH and microorganisms. Saccharomyces cerevisiae have been widely cultured in several waste feedstocks' including cassava and palm oil mill effluents. Nigeria is the largest and fifth leading producer of cassava and oil palm, respectively in the world. During processing, large volume of wastewater are generated as effluents. These wastewaters are known to cause severe environmental impacts including odour pollution and bareness in receiving soil. In aquatic ecosystem both effluents could lead to eutrophication and increased acidity content. Specifically, cassava mill effluent could cause toxicity on fisheries, vegetation, ruminant animals. This study reviews the potentials of Saccharomyces cerevisiae biomass cultured in oil palm and cassava processing effluents for utilization in animal feed. The study showed that biomass cultured in both effluents contain high total essential amino acids (>40g/100g) compare to Food and Agricultural Organization/World Health Organization standard values (33.9g/100g) for feed. Based on proximate composition the results are also promising especially with protein content which is higher than 17%. But the yield was low (approximately 4g/l) in both effluents. In cassava mill effluents, palm oil, heat and fermentation aid in the reduction of cyanide content. Hence, there is the need for research to focus on manipulation of the environmental parameters such as pH and temperature to increase yield, nutrient content (viz: amino acids and proximate compositions). This could aid in minimizing the environmental effects associated with cassava and oil palm processing wastewater.