Protein corona hampers targeting potential of MUC1 aptamer functionalized SN-38 core–shell nanoparticles

The Impact of Nanoparticle Protein Corona on Cytotoxicity, Immunotoxicity and Target Drug Delivery

“…In addition, Davis et al [104] demonstrated that Tf-targeted NPs accumulated in tumor tissue independently of the presence of the targeting ligand (Tf), also if the Tf ligand itself provided greater tumor cell uptake. In another study, Varnamkhasti et al [105] demonstrated how, after incubation in 100% fetal bovine serum (FBS), aptamer-targeted core-shell chitosan NPs carrying an active metabolite of camptotechin (i.e. SN-38) and nontargeted NPs showed similar cytoxicity activity toward human colon cancer cells HT29.…”

Aptamers as smart ligands for nano-carriers targeting

“…Core nanoparticles were coated with drug 325 conjugated to hyaluronic acid. The results confirmed that targeted NPs showed enhanced uptake 326 and cytotoxicity [131]. Another study employed MUC-1aptamer to develop a phototherapy 327 system ( Figure 2).…”

“…129 Nanostructures as a drug carrier can be designed to target specifc cells and tissues and deliver the 130 drug in a stimuli-responsive manner. Up to now, a wide range of nanocariers have been 131 and feasibility of variable routes of administration, including oral application and inhalation. 136 Additionally, the use of nanoparticles enables the controlled release of loaded drug, reduces 137 dosing frequency and improves drug bioavailability.…”

Anti‐MUC1 aptamer: A potential opportunity for cancer treatment

“…Interestingly, this phenomenon had no effect on the cytotoxicity of unmodified NPs, whereas it decreased the cytotoxicity of APT–NPs. The protein corona therefore appears to have a negative effect on targeted drug delivery of NPs …”